19493-45-9 Usage
Description
3-Chloroisoquinoline is a chlorinated isoquinoline derivative, a chemical compound with the molecular formula C9H6ClN. It is known for its potential applications in medicinal chemistry, exhibiting biological activities such as antitumor and antimicrobial properties. This versatile compound also serves as a building block in the production of dyes and pigments, making it a significant player in the realm of organic chemistry and chemical synthesis.
Uses
Used in Pharmaceutical Synthesis:
3-Chloroisoquinoline is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
3-Chloroisoquinoline also finds use in the creation of agrochemicals, contributing to the development of pesticides and other agricultural products designed to protect crops and enhance yields.
Used in Medicinal Chemistry Research:
3-Chloroisoquinoline is employed as a subject of study in medicinal chemistry, where its antitumor and antimicrobial properties are explored for potential treatments of various diseases and infections.
Used in Dye and Pigment Manufacturing:
As a building block in the production of dyes and pigments, 3-Chloroisoquinoline contributes to the coloration and enhancement of various materials in industries such as textiles, plastics, and printing inks.
Check Digit Verification of cas no
The CAS Registry Mumber 19493-45-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,9 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 19493-45:
(7*1)+(6*9)+(5*4)+(4*9)+(3*3)+(2*4)+(1*5)=139
139 % 10 = 9
So 19493-45-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H6ClN/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-6H
19493-45-9Relevant articles and documents
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Haworth,Robinson
, p. 777,781 (1948)
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NaBH4-TMEDA and a palladium catalyst as efficient regio- and chemoselective system for the hydrodehalogenation of halogenated heterocycles
Chelucci, Giorgio,Figus, Susanna
, p. 191 - 209 (2014/07/21)
The pair NaBH4-TMEDA as hydride source and a palladium catalyst in THF prove to be an efficient system for the hydrodehalogenation of halogenated heterocycles with one or more heteroatoms. In general, Pd(OAc) 2-PPh3 rapidly hydrodehalogenates reactive halo-heterocycles such as bromo-pyridines, -quinolines, -thiophenes, -indoles, -imidazoles, etc., at room temperature in very good yields, whereas in most cases PdCl2(dppf) reduces less reactive halides such as chloro-pyridines, -quinolines, -pyrimidines and bromo-indoles, -benzofurans, etc. Moreover, PdCl2(tbpf) shows to be even more active removing the 2- and 5-chlorine from both thiophene and thiazole rings. The reaction conditions tolerate various functional groups, allowing highly chemoselective reactions in the presence of halide, ester, alkyne, alkene and nitrile substituents. Moreover, with a proper selection of the catalyst it is also possible to obtain a good control in the regioselective hydrodehalogenation of a variety of polyhalogenated substrates.
TRPV1 ANTAGONISTS
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Page/Page column 87, (2010/04/30)
Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
