29193-71-3Relevant academic research and scientific papers
Photoredox and weak Br?nsted base dual catalysis: Alkylation of α-thio alkyl radicals
Alfonzo, Edwin,Hande, Sudhir M.
, p. 12590 - 12595 (2020/11/18)
We report the C?H activation of thioethers to α-thio alkyl radicals and their addition to electron-deficient olefins to afford alkylated products through dual photoredox and weak Br?nsted base catalysis. Mechanistic studies are consistent with a two-step activation mechanism, where oxidation of thioethers to their corresponding sulfide radical cations by an acridinium photoredox catalyst is followed with deprotonation by trifluoroacetate to generate α-thio alkyl radicals and trifluoroacetic acid (TFA). Experimental studies support the involvement of TFA in all subsequent steps leading to product formation.
CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY
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Paragraph 00102, (2014/05/24)
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY
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Sheet 8, (2012/08/28)
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
STRAIN AND SELECTIVITY: PARTNERS FOR ORGANIC SYNTHESIS
Trost, Barry M.
, p. 139 - 150 (2007/10/02)
The development of two new small-ring conjunctive reagents, (E)-2-(hydrohymethyl)cyclopropyl phenyl sulphide and 1,1-bis(benzenesulphonyl)cyclopropane, are reported.The former permits a synthesis of 2,4-disubstituted cyclobutanones and (E)-4-phenylthio-4-
Bifunctional Cyclopropyl Reagents: Stereocontrolled Approach to Vinyl Sulfides and Chemodifferentiated 1,4-Dicarbonyl Systems
Trost, Barry M.,Ornstein, Paul L.
, p. 748 - 751 (2007/10/02)
The use of (E)-2-(hydroxymethyl)cyclopropyl phenyl sulfide as a useful conjunctive reagent, particularly in a stereocontrolled synthesis of vinyl sulfides, is reported.
Preparation and Reactions of Novel Cyclic β-Oxosulphonium Salts obtained by the Acid-induced Cycisation of 1-Diazo-ω-phenylthio-2-alkanones
Flowers, William T.,Freitas, Ana M.,Holt, Geoffrey,Purkiss, Stuart C.
, p. 1119 - 1124 (2007/10/02)
With perchloric acid, the diazo-ketones PhSnCOCHN2 (1a)-(1d) give the corresponding cyclic β-oxosulphonium salts (2a)-(2d); the p-chlorophenyl analogue of (2d) was similarly prepared.The salts (2a), (2c), and (2d) react with triphenylphosphine at C(2) to give the acyclic phosphonium salts (3a), (3c), and (3d) and, analogously, with potassium O-ethyl dithiocarbonate to give the corresponding acyclic O-ethyl dithiocarbonates (3f), (3g), and (3h).All the reactions of the salt (2b) with nucleophiles gave either 1-phenylthiobut-3-en-2-one (11) or products of its Michael addition.Salts (2c) and (2d) with sodium methoxide in methanol provide, respectively, methyl ω-phenylthio-butanoate and -pentanoate in a process that involves the loss of a methylene group.These and other reactions are considered to proceed via ylide intermediates; the intermediate derived by the deprotonation of (2d) being isolated, whereas that from (2c) rearranged to give 3-phenylthiocyclopentanone.
