31067-02-4

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 141-78-6 ethyl acetate 
• 98-86-2 acetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 75-36-5 acetyl chloride 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 100-66-3 methoxybenzene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 90-96-0 bis(p-methoxyphenyl)methanone 
• 18523-10-9 1,1-Di--2-phenylthio-aethylen 
• 6325-62-8 N,1-bis(4-methoxyphenyl)ethan-1-imine 
• 1178365-18-8 1-amino-1,1-bis(4-methoxyphenyl)ethane 
• 471254-25-8 (±)-4-methoxy-N-(1-(4-methoxyphenyl)ethyl)aniline 
• 38512-67-3 2,2-bis-(4-methoxy-phenyl)-cyclopropanecarboxylic acid 
• 384842-35-7 1,1-bis(4-methoxyphenyl)propanol 
• 4663-13-2 1,1-bis(4-methoxyphenyl)propene 
• 101544-53-0 1,1-Bis(4-methoxyphenyl)propan-2-one 
• 4741-75-7 1,1-bis(4-methoxyphenyl)-2-methylpropane 

Relevant academic research and scientific papers

Base-promoted addition of DMA with 1,1-diarylethylenes: Application to a total synthesis of (-)-sacidumlignan B

A base-promoted addition of DMA (N,N-dimethylacetamide) to 1,1-diarylethylenes has been developed, and it provides a new strategy for the synthesis of N,N-dimethyl-4,4-diarylbutanamides from 1,1-diarylethylenes at room temperature. This method allows us to achieve the goal of synthesizing (-)-sacidumlignan B, and provides simple operation and broad substrate scope by avoiding the use of transition metal catalysts.

Facile synthesis of indolelactones using Mn(III)-based oxidative substitution-cyclization reaction

Based on the oxidation of indole with Mn(OAc)3 in the presence of 1,1-diarylethenes affording 3-vinyl-substituted indoles, a similar oxidation using indole-2-carboxylic acids was evaluated in order to effectively introduce the substituent group to the C-3 position of the indolecarboxylic acids. The coupling reaction followed by oxidative cyclization smoothly proceeded at room temperature in an AcOH-HCO2H mixed solvent to give the desired indolelactones in high yields. The reaction details, the structure determination of the products and a brief reaction mechanism are described.

AUTOPHAGY INDUCER COMPOUNDS

The invention relates to difluoro heterocyclic compounds and their medical uses. Compounds of the invention have the general formula (I): wherein each X is identical and forms part of an ethoxyamine basic side chain which includes a 5- or 6-membered heterocyclic ring, and the heterocyclic ring X is selected from the group consisting of: formula (II).

Scandium(III) Trifluoromethanesulfonate Catalyzed Selective Reactions of Donor–Acceptor Cyclopropanes with 1,1-Diphenylethanols: An Approach to Polysubstituted Olefins

An unexpected synthetic approach to polysubstituted olefins through the scandium(III) trifluoromethanesulfonate catalyzed ring-opening reaction of donor–acceptor cyclopropanes with 1,1-diphenylethanols was developed. The reactions, which are experimentally easy to handle, feature tolerance of various functional groups and mild reaction conditions. On the basis of experimental evidence, a plausible mechanism was also proposed.

A simple and efficient copper oxide-catalyzed Barbier-Grignard reaction of unactivated aryl or alkyl bromides with ester

An efficient one-pot route to synthesize tertiary alcohol compounds using Barbier-Grignard reaction of unactivated alkyl or aryl bromides with ester in THF at 65 C catalyzed by CuO has been developed and systematically investigated. A wide range of substituted tertiary alcohol compounds were obtained in good to high yields. The reaction is highly chemoselective. The mechanism involving the leaving group of R2O-group is discussed.

A simple and efficient copper oxide-catalyzed Barbier-Grignard reaction of unactivated aryl or alkyl bromides with ester

An efficient one-pot route to synthesize tertiary alcohol compounds using Barbier-Grignard reaction of unactivated alkyl or aryl bromides with ester in THF at 65 °C catalyzed by CuO has been developed and systematically investigated. A wide range of substituted tertiary alcohol compounds were obtained in good to high yields. The reaction is highly chemoselective. The mechanism involving the leaving group of R2O-group is discussed.

The rhodium-catalysed 1,2-addition of arylboronic acids to aldehydes and ketones with sulfonated S-Phos

The rhodium-catalysed 1,2-addition of arylboronic acids to aryl aldehydes has been accomplished in high yield using sulfonated S-Phos, a water-soluble biaryl phosphine ligand which allows for catalyst recycling. The catalytic protocol has also been successful in the challenging arylation of ketones.

"Nafion"-functionalized mesoporous MCM-41 silica shows high activity and selectivity for carboxylic acid esterification and Friedel-Crafts acylation reactions

Hybrid organic-inorganic MCM-41 silicas functionalized with perfluoroalkylsulfonic acid groups analogous to that of Nafion were prepared in a simple single step by a condensation reaction between surface silanol groups of the mesoporous silicas and 1,2,2-trifluoro-2-hydroxy-1-trifluoromethyl-ethane sulfonic acid Beta-sultone. The catalysts showed very high activity for the esterification of long-chain fatty acids with ethanol and high-molecular-weight alcohols with essentially complete selectivity at high conversion (>95%). Acylation of anisole was also possible, with high selectivity for 4-methoxyacetophenone. The catalysts showed more activity conversion than commercial Nafion-silica composite catalysts.

Characterization of persistent intermediates generated upon inclusion of 1,1-diarylethylenes within CaY zeolite: Spectroscopy and product studies

Inclusion of 1,1-diarylethylenes within activated CaY results in the formation of colored samples that are stable for prolonged periods. For example, diphenylethylene generates a green color within CaY. Two reactive intermediates have been shown to be res

Activation conditions play a key role in the activity of zeolite CaY: NMR and product studies of Bronsted acidity

CaY, activated under different conditions, was characterized with 1H, 31P, and 1H/27A] double resonance MAS NMR. The 1H MAS NMR spectra of CaY, calcined in an oven at 500 °C, shows resonances from H2O (bound to Ca2+ and the zeolite framework), CaOH+, aluminum hydroxides, silanols, and Bronsted acid sites. No evidence for Lewis acidity is observed on adsorption of trimethylphosphine, and an estimate of ≈16 Bronsted acid sites per unit cell is obtained for this sample. CaY activated in an oven at higher temperatures contains less water, but all the other species are still present. In contrast, CaY activated by slow ramping of the temperature under vacuum to 500 or 600 °C shows a much lower concentration of Bronsted acid sites (1/unit cell). Again, no evidence for Lewis acidity was observed. These NMR results have been utilized to understand the very different product distributions that are observed for reactions of 1,1- and 1,2-diarylethylenes in zeolite CaY activated in an oven (in air) and under vacuum. Samples with high concentrations of Bronsted acid sites react stoichiometrically with these sites, yielding diarylalkanes. At low concentrations, the Bronsted acid sites can act catalytically resulting in isomerization reactions.