4146-43-4Relevant academic research and scientific papers
Coordinatively Unsaturated Lanthanide(III) Helicates: Luminescence Sensors for Adenosine Monophosphate in Aqueous Media
Sahoo, Jashobanta,Arunachalam, Rajendran,Subramanian, Palani S.,Suresh, Eringathodi,Valkonen, Arto,Rissanen, Kari,Albrecht, Markus
, p. 9625 - 9629 (2016)
Coordinatively unsaturated double-stranded helicates [(H2L)2Eu2(NO3)2(H2O)4](NO3)4, [(H2L)2Tb2(H2O)6](NO3)6, and [(H2L)2Tb2(H2O)6]Cl6(H2L=butanedioicacid-1,4-bis[2-(2-pyridinylmethylene)hydrazide]) are easily obtained by self-assembly from the ligand and the corresponding lanthanide(III) salts. The complexes are characterized by X-ray crystallography showing the helical arrangement of the ligands. Co-ligands at the metal ions can be easily substituted by appropriate anions. A specific luminescence response of AMP in presence of ADP, ATP, and other anions is observed. Specificity is assigned to the perfect size match of AMP to bridge the two metal centers and to replace quenching co-ligands in the coordination sphere.
Synthesis, spectroscopic and electrochemical characterisation of binuclear dioxomolybdenum complexes derived from disalicylaldehyde succinoyldihydrazone
Ahmed, Aziz,Chanu, Oinam B.,Koch, Angira,Lal
, p. 161 - 168 (2012)
The diamagnetic dioxomolybdenum (VI) complexes [(MoO2) 2(L).(H2O)2] where H4L = H 4slsh have been isolated in solid state from the reaction of MoO 2(acac)2 and disalicylaldehyde succinoyldihydrazone (H4L) in 3:1 molar ratio in ethanol at higher temperature. The reaction of the complex with electron donor bases gives diamagnetic molybdenum(VI) complexes having composition [(MoO2) 2(L)(A)2]·H2O (where A = pyridine (py, 2), 2-picoline (2-pic, 3), 3-picoline (3-pic, 4), 4-picoline (4-pic, 5). The composition of the complexes have been established by analytical, thermo-analytical data. The structure of the molybdenum (VI) complexes has been established by mass, electronic, IR, 1H NMR and CV spectral studies. The dihydrazone is coordinated to the metal centres in staggered configuration in all the complexes. The electronic spectra of the complexes are dominated by strong charge transfer bands. All of the complexes involve six coordinated molybdenum centre with octahedral arrangement of donor atoms.
Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films
Mahon, Clare S.,McGurk, Christopher J.,Watson, Scott M. D.,Fascione, Martin A.,Sakonsinsiri, Chadamas,Turnbull, W. Bruce,Fulton, David A.
, p. 12913 - 12918 (2017)
We describe single-chain polymer nanoparticles (SCNPs) possessing intramolecular dynamic covalent crosslinks that can transform into polymer films through a molecular recognition-mediated crosslinking process. The SCNPs utilise molecular recognition with surface-immobilised proteins to concentrate upon a substrate, bringing the SCNPs into close spatial proximity with one another and allowing their dynamic covalent crosslinkers to undergo intra- to interpolymer chain crosslinking leading to the formation of polymeric film. SCNPs must possess both the capacity for specific molecular recognition and a dynamic nature to their intramolecular crosslinkers to form polymer films, and an investigation of the initial phase of film formation indicates it proceeds from features which form upon the surface then grow predominantly in the xy directions. This approach to polymer film formation presents a potential method to “wrap” surfaces displaying molecular recognition motifs—which could potentially include viral, cellular and bacterial surfaces or artificial surfaces displaying multivalent recognition motifs—within a layer of polymer film.
Supramolecular interactions in a family of dinuclear helicates in the solid-state
Kruger, Paul E.,Wilson, Benjamin H.
, p. 1 - 10 (2020)
Metallo-helicates are a commonly encountered assembly within supramolecular chemistry. Interest in these architectures stems from their inherent helical chirality which positions them for a diverse range of applications such as catalysis and non-linear optics (NLO). The current study uses Co(II) dinuclear double helicates as versatile supramolecular synthons. The ditopic ligand, L, features two tridentate quinolinyl-hydrazone binding sites imparting it with hydrogen bond donors and π-faces for secondary supramolecular interactions. Incorporation of L into [Co2(L)2]4+ helical assemblies results in a helical cationic supramolecular synthon with moieties predisposed to forming π-π stacking and hydrogen bond interactions. The single-crystal X-ray structures of [Co2(L)2]X4 (X?=?ClO4?, BF4? and CF3SO3?) revealed a variety of anion dependent hydrogen bond networks arising through the interaction of the hydrazide hydrogen with the anion. These interactions in turn strongly influence the nature of the π-π stacking interactions of the quinoline moieties which can be analysed via the Hirshfield surface.
Synthesis and characterization of heterobimetallic Ni(II)-Zn(II) complexes from bis(2-hydroxy-1 -naphthaldehyde)succinoyldihydrazone
Lal,Chakraborty,Chanu,Choudhury,Borthakur,Copperfield,Kumar
, p. 1239 - 1251 (2010)
Monometallic zinc(II) and nickel(II) complexes, [Zn(H2nsh)(H2O)] (1) and [Ni(H2nsh)(H2O)2] (2), have been synthesized in methanol by template method from bis(2-hydroxy-1-naphthaldehyde)succinoyldihydrazone (H4nsh). Reaction of monometallic complexes with alternate metal(II) acetates as a transmetallator in 1: 3 molar ratio resulted in the formation of heterobimetallic complexes [NiZn(nsh)(A)3] and [ZnNi(nsh)(A′)2] (A′ = H2O (3), py (4), 2-pic (5), 3-pic (6), 4-pic (7)), (A' = H2O (8), py (9), 2-pic (10), 3-pic (11), and 4-pic (12)). The complexes have been characterized by elemental analyzes, mass spectra, molar conductance, magnetic moments, electronic, EPR, and IR spectroscopies. All of the complexes are non-electrolytes. Monometallic zinc(II) is diamagnetic while monometallic nickel(II) complex and all heterobimetallic complexes are paramagnetic. The metal centers in heterobimetallic complexes are tethered by dihydrazone and naphthoxo bridging. Zinc(II) is square pyramidal; nickel(II) is six-coordinate distorted octahedral except [ZnNi(nsh)(A)2], in which nickel(II) has square-pyramidal geometry. The displacement of metal center in monometallic complexes by metal ion has been observed in the resulting heterobimetallic complexes.
Synthesis and spectral characterization of homobimetallic molybdenum(VI) complexes derived from bis(2-hydroxy-1-naphthaldehyde)succinoyldihydrazone
Lal, Ram A.,Chakrabarty, Mithun,Choudhury, Sanjesh,Ahmed, Aziz,Borthakur, Roshmita,Kumar, Arvind
, p. 163 - 175 (2010)
The reaction of bis(2-hydroxy-1-naphthaldehyde)succinoyldihydrazone with bis(acetylaceto-nato)dioxomolybdenum(VI) (MoO2(acac)2) in 1: 3 molar ratio in EtOH: water mixture (95: 5) affords a complex of composition [(MoO2)2(nsh)(H2O)2]·C2H5OH. The reaction of [(MoO2)2 (nsh)(H2O)2]·C2H5OH with Lewis bases, namely pyridine,2-picoline,3-picoline, and 4-picoline, yields[(MoO2)2(nsh)(B)2]·C2H5OH (where B=pyridine,2-picoline,3-picoline, and 4-picoline). Further, when this complex was reacted with 1,10-phenanthroline and 2,2′-bipyridine in 1:3 molar ratio in anhydrous ethanol the binuclear complexes [(μ2-O)2(MoO2)2 (H4nsh)(phen)]·C2H5OH and [(μ2-O)2(MoO2)2 (H4nsh)(bpy)]·C2H5OH were obtained. All of the complexes have been characterized by analytical, magnetic moment, and molar conductivity data. The structures of the complexes have been discussed in the light of electronic, IR, 1H NMR, and 13C NMR spectroscopy.
FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES
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Paragraph 0175; 0240; 0243, (2021/06/22)
The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.
The fabrication and characterization of a supramolecular Cu-based metallogel thin-film based Schottky diode
Kumar, Vivek,Upadhyay, Rishibrind Kumar,Bano, Daraksha,Chandra, Subhash,Kumar, Deepak,Jit, Satyabrata,Hasan, Syed Hadi
, p. 6273 - 6280 (2021/04/16)
In the present study, a stable supramolecular Cu(ii)-metallogel has been synthesized based on copper(ii) acetate monohydrate and succinic acid, engineered as a low-molecular-weight organic gelator. The mechanical assets of the Cu-H4L metallogel have been explored through a rheological investigation. Further, the aggregation of the synthesized metallogel has been well establishedviaseveral experiments using Job plots and ESI-MS. Apart from this, the morphology of the synthesized supramolecular metallogel was scrutinizedviaFESEM, TEM, and AFM studies, revealing the self-assembled thread-like morphology of the Cu-H4L metallogel. The functional group, elemental composition, crystalline behaviour, and thermal stability of the Cu-H4L metallogel were probedviaFT-IR, XPS, P-XRD, and TGA studies, respectively. The optical properties of the Cu-H4L metallogel reflected its semiconducting nature. Thus, based on the semiconducting properties of the Cu-H4L metallogel, we have successfully fabricated an active electronic device: a ‘Schottky diode’.
Synthesis, characterization, crystal structure, and reactivity of heterobimetallic dioxovanadium(V) complexes containing multidentate hydrazone ligands
Kurbah, Sunshine D.,Kumar, Arvind,Sanentiba Ozukum,Syiemlieh, Ibanphylla,Lal, Ram A.
, p. 2969 - 2985 (2017/10/07)
Two new heterobimetallic complexes of the composition [(VO2)2(μ3-slsch){Na2(μ-H2O)2(H2O)2}]n (1) and [(VO2)2(μ3-npsch){Na2(μ-H2O)2(H2O)2}(DMF)]n (2) were obtained by reaction of the ligand and vanadium pentoxide in a 1:1 molar ratio in methanol in the presence of Na2CO3 (2 equivalents). The complexes obtained were characterized using various spectroscopic studies. The structures of both the complexes were established by single crystal X-ray crystallographic study. We have also explored the catalytic behavior of the complexes in oxidative bromination of phenol red, which is the bio-inspired reaction catalyzed by an enzyme haloperoxidase.
Azolylthioacetamides as a potent scaffold for the development of metallo-β-lactamase inhibitors
Xiang, Yang,Chang, Ya-Nan,Ge, Ying,Kang, Joon S.,Zhang, Yi-Lin,Liu, Xiao-Long,Oelschlaeger, Peter,Yang, Ke-Wu
supporting information, p. 5225 - 5229 (2017/11/13)
In an effort to develop new inhibitors of metallo-β-lactamases (MβLs), twenty-eight azolylthioacetamides were synthesized and assayed against MβLs. The obtained benzimidazolyl and benzioxazolyl substituted 1–19 specifically inhibited the enzyme ImiS, and 10 was found to be the most potent inhibitor of ImiS with an IC50 value of 15 nM. The nitrobenzimidazolyl substituted 20–28 specifically inhibited NDM-1, with 27 being the most potent inhibitor with an IC50 value of 170 nM. Further studies with 10, 11, and 27 revealed a mixed inhibition mode with competitive and uncompetitive inhibition constants in a similar range as the IC50 values. These inhibitors resulted in a 2–4-fold decrease in imipenem MIC values using E. coli cells producing ImiS or NDM-1. While the source of uncompetitive (possibly allosteric) inhibition remains unclear, docking studies indicate that 10 and 11 may interact orthosterically with Zn2 in the active site of CphA, while 27 could bridge the two Zn(II) ions in the active site of NDM-1 via its nitro group.
