42292-18-2

Basic information

• Product Name: 3-Aminopropylbis(trimethylsiloxy)methylsilane
• Synonyms: 3-(3-Aminopropyl)heptamethyltrisiloxane;3-[1,3,3,3-Tetramethyl-1-[(trimethylsilyloxy)disiloxanyl]propylamine;3-Aminopropylbis(trimethylsiloxy)methylsilane
• CAS NO: 42292-18-2
• Molecular Formula: C₁₀H₂₉NO₂Si₃
• Molecular Weight: 279.6
• Mol File: 42292-18-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 254 °C
• Flash Point: 108 °C
• Appearance: /
• Density: 0.881
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.428
• PKA: 10.40±0.10(Predicted)
• CAS DataBase Reference: 3-Aminopropylbis(trimethylsiloxy)methylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminopropylbis(trimethylsiloxy)methylsilane(42292-18-2)
• EPA Substance Registry System: 3-Aminopropylbis(trimethylsiloxy)methylsilane(42292-18-2)

Safety Data

• TSCA: No
• Hazardous Substances Data: 42292-18-2(Hazardous Substances Data)

Usage

General Description

3-Aminopropylbis(trimethylsiloxy)methylsilane, also known as APTMS, is a chemical compound with the molecular formula C11H29NOSi2. It belongs to the class of organosilicon compounds and contains a silicon atom bonded to three methyl groups, a trimethylsiloxy group, and an aminopropyl group. APTMS is commonly used as a coupling agent in the production of polymers, adhesives, and coatings, as well as a surface modifier for nanoparticles and inorganic materials. Its unique chemical structure allows it to improve the adhesion and compatibility between different materials, making it a valuable ingredient in various industrial applications. Additionally, APTMS has been studied for its potential use in biomedical and pharmaceutical fields due to its ability to modify surfaces and enhance the interaction between biomolecules and materials. Overall, APTMS is a versatile chemical with diverse applications in material science, industry, and medical research.

InChI:InChI=1/C10H29NO2Si3/c1-14(2,3)12-16(7,10-8-9-11)13-15(4,5)6/h8-11H2,1-7H3

Synthetic route

3-(N-trimethylsilyl-3-aminopropyl)heptamethyltrisiloxane (63672-10-6) → 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2)

Conditions	Yield
In ethanol for 1h;	95%
With water In isopropyl alcohol

Hexamethyldisiloxane (107-46-0) + 3-(diethoxy-methyl-silanyl)-propylamine (3179-76-8) → 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2)

Conditions	Yield
With tetramethyl ammoniumhydroxide at 100℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;	68%

Hexamethyldisiloxane (107-46-0) + gamma-aminopropylmethyldimethoxysilane (3663-44-3) → 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2)

Conditions	Yield
With tetramethyl ammoniumhydroxide at 90℃; for 2h; Inert atmosphere;	52.9%

Hexamethyldisiloxane (107-46-0) + 3-(ethoxy-methoxymethyl-methyl-silanyl)-propylamine → 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2)

Conditions	Yield
With [C5H5N+C18H38]*NTf2; oxygen at 22℃; under 750.075 Torr; Electrochemical reaction;	32%

1,1,1,3,5,5,5-heptamethyltrisiloxan (1873-88-7) → 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: 54 percent / H2PtCl6*6H2O / tetrahydrofuran / 120 - 145 °C 2: 95 percent / ethanol / 1 h View Scheme
Multi-step reaction with 2 steps 1: H2PtCl6*6H2O / propan-2-ol 2: H2O / propan-2-ol View Scheme

1,3,5-trichloro-2,4,6-triazine (108-77-0) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2,4-dichloro-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine (207562-46-7)

Conditions	Yield
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 1.5h; pH=3 - 6.5;	95%
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 1.5h; pH=3 - 6.5;	95%
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; pH=6.5;	95%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2,4-dichloro-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)-oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions	Yield
With sodium carbonate In water; acetone at 0 - 10℃; for 1.5h; pH=3 - 6.5;	95%

gloutaric dichloride (2873-74-7) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → N1,N5-bis(3-(trimethoxysilyl)propyl)glutaramide

Conditions	Yield
Stage #1: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine With triethylamine In toluene at 0℃; for 0.5h; Inert atmosphere; Stage #2: gloutaric dichloride In toluene at 0 - 20℃; for 3.5h; Inert atmosphere;	92%

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + Thioctic acid (1077-28-7, 62-46-4) → 5-(1,2-dithiolan-3-yl)-N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-disiloxanyl}propyl)pentanamide (1026779-50-9)

Conditions	Yield
Stage #1: Thioctic acid With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine With triethylamine In tetrahydrofuran for 20h;	80%

oxalyl dichloride (79-37-8) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + 3-Phenylpropionic acid (501-52-0) → 3-phenyl-N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)-propanamide (1027627-90-2)

Conditions	Yield
With sodium chloride; N-ethyl-N,N-diisopropylamine In ethyl acetate; N,N-dimethyl-formamide; acetonitrile	76%

cyanoacetic acid chloride (16130-58-8) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → cyano-N-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]acetamide (851974-02-2)

Conditions	Yield
Stage #1: cyanoacetic acid chloride; 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine; triethylamine In dichloromethane at 32℃; for 0.333333h; dropwise addition; Stage #2: for 2h; Heating / reflux;	70%

oxalyl dichloride (79-37-8) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)benzamide (1027627-89-9)

Conditions	Yield
With sodium chloride; N-ethyl-N,N-diisopropylamine; benzoic acid In dichloromethane; ethyl acetate; N,N-dimethyl-formamide	70%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + p-aminoethylbenzoate (94-09-7) → 2,4-bis(ethyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; p-aminoethylbenzoate With potassium carbonate In water; butanone at 0 - 70℃; for 6h; Inert atmosphere; Stage #2: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine With sodium carbonate In water; butanone at 70℃; for 4h;	70%

N,N-Dimethylacrylamide (2680-03-7) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → C15H38N2O3Si3

Conditions	Yield
In ethanol at 20℃; for 96h;	69%

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → heptamethyl-3-<3-<(pentachlorocyclotriphosphazenyl)amino>propyl>trisiloxane

Conditions	Yield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; triethylamine In benzene for 5h; Ambient temperature;	52.6%

ethyl 3-{4-[4-chloro-6-(methoxyphenyl)[1,3,5]triazin-2-ylamino]phenyl}-2-cyanoacrylate + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2-(ethyl 4'-ylamino-α-cyanocinnamate)-4-(4-methoxyphenyl)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions	Yield
In toluene at 90℃; for 2h;	47%

butyl 4-{4-chloro-6-[4-(2-cyano-2-methanesulfonylvinyl)phenylaminol][1,3,5]triazin-2-ylamino}benzoate (803699-13-0) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2-(4'-ylamino-2-methanesulfonylacrylonitrile)-4-(butyl 4'-ylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-disiloxanyl]propyl-3-ylamino}-s-triazine (803699-11-8)

Conditions	Yield
In toluene at 90℃; for 2h;	26%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + 4-methoxycarbonyl aniline (619-45-4) → 2,4-bis(methyl 4'-aminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; 4-methoxycarbonyl aniline With potassium carbonate In water; butanone at 0 - 70℃; for 7h; Inert atmosphere; Stage #2: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine With sodium carbonate In water; butanone for 1h;	18%

C26H25ClN6O4 + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2-(ethyl 4'-ylamino-α-cyanocinnamate)-4-(butyl 4'-ylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine (803699-07-2)

Conditions	Yield
In toluene at 90℃; for 2h;	12%

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + ethyl chlorocarbonylacetate (36239-09-5) → Ethyl N-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]malonamide (851974-10-2)

Conditions	Yield
Stage #1: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine; ethyl chlorocarbonylacetate; triethylamine In dichloromethane at 10℃; for 0.5h; dropwise addition; Stage #2: for 2h; Heating / reflux;

2-methylmalonyl dichloride (39619-07-3) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → Methyl N-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-disiloxanyl]propyl]malonamate (209330-73-4)

Conditions	Yield
With triethylamine In dichloromethane; water

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + hydrocinnamic acid chloride (645-45-4) → 3-phenyl-N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)-propanamide (1027627-90-2)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + benzoyl chloride (98-88-4) → N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)benzamide (1027627-89-9)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + D-Glucono-1,5-lactone (90-80-2) → C16H39NO8Si3 (164063-67-6)

Conditions	Yield
In methanol for 6h; Reflux;	2.369 g

4-amino-benzoic acid butyl ester (94-25-7) + 1,3,5-trichloro-2,4,6-triazine (108-77-0) + 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) + 2-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}-propan-1-amine → 2,4-bis(n-butyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine + butyl 4-({4-{[4-(butoxycarbonyl)-phenyl]amino}-6-[(2-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}-propyl)amino]-1,3,5-triazin-2-yl}amino)benzoate

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine; 2-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}-propan-1-amine With 2,6-dimethylpyridine In ethyl acetate at 0 - 20℃; for 2h; Stage #2: 4-amino-benzoic acid butyl ester With pyridine In ethyl acetate at 70℃; for 3h; Overall yield = 60 %; Overall yield = 49 g;

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → C64H94N12O11Si4

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: potassium carbonate / toluene / 1.33 h / Inert atmosphere; Reflux 3: hydrogenchloride / ethanol; water; isopropyl alcohol / 4 h View Scheme
Multi-step reaction with 3 steps 1: sodium carbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: potassium carbonate / toluene / 1.33 h / Reflux; Inert atmosphere 3: hydrogenchloride / ethanol; water; isopropyl alcohol / 4 h View Scheme
Multi-step reaction with 3 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: potassium carbonate / toluene / 1.33 h / Inert atmosphere; Reflux 3: hydrogenchloride / ethanol; water; isopropyl alcohol / 4 h / 20 °C / pH 7 View Scheme

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2,4-bis(ethyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: toluene / 1.5 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: toluene / 1.5 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: toluene / 1.5 h / Reflux View Scheme

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2,4-bis(n-butyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: potassium carbonate / toluene / 1.33 h / Inert atmosphere; Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: potassium carbonate / toluene / 1.33 h / Reflux; Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: potassium carbonate / toluene / 1.33 h / Inert atmosphere; Reflux View Scheme

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2,4-bis(n-pentyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: sodium hydrogencarbonate / toluene / 0.33 h / 115 °C / Microwave irradiation View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / butanone; water / 6 h / 0 - 70 °C / Inert atmosphere 1.2: 4 h / 70 °C 2.1: potassium carbonate / butanone; water / 17.5 h / 0 - 70 °C / Inert atmosphere 2.2: 5 h / 70 °C View Scheme
Multi-step reaction with 3 steps 1.1: sodium carbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2.1: toluene / 1.5 h / Reflux 3.1: potassium carbonate / butanone; water / 17.5 h / 0 - 70 °C / Inert atmosphere 3.2: 5 h / 70 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: sodium hydrogencarbonate / toluene / 0.33 h / 115 °C / Microwave irradiation View Scheme

3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine (42292-18-2) → 2,4-bis[(1,1,3,3-tetramethylbutyl)-4’-diylaminobenzamide]-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: sodium hydrogencarbonate / toluene / 0.33 h / 115 °C / Microwave irradiation View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: sodium hydrogencarbonate / toluene / 0.33 h / 115 °C / Microwave irradiation View Scheme

Upstream product

• 107-46-0 Hexamethyldisiloxane 
• 3663-44-3 gamma-aminopropylmethyldimethoxysilane 
• 3179-76-8 3-(diethoxy-methyl-silanyl)-propylamine 
• 1873-88-7 1,1,1,3,5,5,5-heptamethyltrisiloxan 
• 63672-10-6 3-(N-trimethylsilyl-3-aminopropyl)heptamethyltrisiloxane 

Downstream Products

• 1027627-90-2 3-phenyl-N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)-propanamide 
• 1027627-89-9 N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)benzamide 
• 803699-11-8 2-(4'-ylamino-2-methanesulfonylacrylonitrile)-4-(butyl 4'-ylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-disiloxanyl]propyl-3-ylamino}-s-triazine 
• 803699-07-2 2-(ethyl 4'-ylamino-α-cyanocinnamate)-4-(butyl 4'-ylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine 

Relevant articles and documents

Thermodynamics properties of micellization of organosilicone modified gluconamide-type surfactant

Thermodynamic properties of micellization of N-3-propylmethyltrisiloxane-N- glucosylamine in water over a temperature range of 298 to 313 K been studied with surface tension method. On the basis of these results, the thermodynamic parameters i.e., Gibbs energy (δG? m), enthalpy (δS? m) and entropy (δH? m) of micellization have been evaluated.

The effects of the organic groups attached at the silicone atoms of the organosilane-based gemini nonionic surfactants on their surface activities

A novel trisiloxane gemini nonionic surfactant was synthesized by the reaction of 3-(diethoxy(methyl)silyl)propan-1-amine with hexamethyldisiloxane to get 3-(trisiloxane)propan-1-amine, which was further reacted with glutaroyl dichloride to form the surfactant molecule, N1,N5-bis(3- (trisiloxane)propyl)glutaramide (3). Some related compounds were also prepared, including N1,N5-bis (3-(trimethoxysilyl)propyl) glutaramide (1), and N1,N5-bis(3-(diethoxy(methyl)silyl) propyl)glutaramide (2). All prepared compounds were analyzed by IR, 1H-NMR and13C-NMR to confirm their structures. Their interfacial activities, including surface tension and wetting ability, were measured. These surface activities were compared each other and a discussion was carried out on how the organic groups attached on the silicone atoms affect their surface tension and wetting ability. To explain the superior surface activities of the molecules 3, a hypothesis was proposed about a cyclic hydrophobic core area that could be formed by the two hydrophobic chains and the linker of the gemini molecule due to the dispersion force (Van der Waals force) between the two trisiloxane moieties, which close the hydrophobic cycle inside the molecule.