5221-42-1

Basic information

• Product Name: 4-ACETAMIDOPYRIDINE
• Synonyms: 4-acetylaminopyridine;n-(4-pyridyl)-acetamid;n-4-pyridinyl-acetamid;n-4-pyridinylacetamide;phillips2038;N-(4-PYRIDYL)ACETAMIDE;4-ACETAMIDOPYRIDINE;AKOS 93468
• CAS NO: 5221-42-1
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15
• EINECS: 226-018-0
• Mol File: 5221-42-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 152 °C
• Boiling Point: 250.42°C (rough estimate)
• Flash Point: 162.033 °C
• Appearance: /
• Density: 1.1778 (rough estimate)
• Vapor Pressure: 6.64E-05mmHg at 25°C
• Refractive Index: 1.5660 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-ACETAMIDOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETAMIDOPYRIDINE(5221-42-1)
• EPA Substance Registry System: 4-ACETAMIDOPYRIDINE(5221-42-1)

Safety Data

• RTECS: AC7875000
• Hazardous Substances Data: 5221-42-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8N2O/c1-6(10)9-7-2-4-8-5-3-7/h2-5H,1H3,(H,8,9,10)

Upstream product

• 504-24-5 4-aminopyridine 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 108-22-5 Isopropenyl acetate 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 1453-82-3 isonicotinamide 
• 507-09-5 tiolacetic acid 
• 64-19-7 acetic acid 
• 127-19-5 N,N-dimethyl acetamide 
• 75-05-8 acetonitrile 
• 105-45-3 acetoacetic acid methyl ester 
• 1363906-80-2 1-acetyl-2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidinium tetraphenylborate 

Downstream Products

• 110058-13-4 N-[1-(2,4-dinitro-phenyl)-1H-[4]pyridyliden]-acetamide; hydrochloride 
• 2632-99-7 trans-4,4'-azobis(pyridine) 
• 79371-42-9 N-(3-nitropyridin-4-yl)acetamide 
• 20815-54-7 (E)-1-pyridyl-2-[4-(bromo)phenyl]diazene 
• 13535-03-0 N-(3-bromopyridin-4-yl)acetamide 
• 36793-31-4 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-acetamidopyridinium iodide 
• 145255-15-8 N-(3-aminopyridin-4-yl)acetamide 
• 54-96-6 3,4-diaminopyridine 
• 14906-56-0 4-Acetamino-pyridin-1-oxid 
• 127269-21-0 (2-Chloro-phenyl)-pyridin-4-yl-diazene 
• 20815-53-6 4-(4-chlorophenylazo)pyridine 
• 2569-58-6 (E)-4-phenylazopyridine 

Relevant articles and documents

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Synthesis of unsymmetrical urea from aryl- or pyridyl carboxamides and aminopyridines using PhI(OAc)2via in situformation of aryl- or pyridyl isocyanates

A tandem synthesis of unsymmetrical ureas (N-aryl-N′-pyridylurea andN,N′-bipyridylurea) from aryl- or pyridyl carboxamides and aminopyridinesviaHofmann rearrangement has been reported. In particular, benzamides, picolinamide, nicotinamide, and isonicotinamide generate reactive intermediate isocyanates,in situ, in the presence of PhI(OAc)2, which upon further reaction with aminopyridines form urea derivatives. As the formation of pyridylisocyanates from their corresponding carboxamidesviaHofmann rearrangement remained unexplored previously, attempts have been made to trap the isocyanates. While the three pyridylisocyanates were trapped as their corresponding carbamates, 3-pyridylisocyanate was isolated and characterized. Unlike closely related previous methods reported for urea synthesis, the current method avoids direct use of isocyanates or eliminates the use of toxic phosgene for thein situgeneration of isocyanates.

Method for preparing amide by visible light-induced metal-free participation (by machine translation)

The method for preparing the amide in the, preparation method of the novel amide disclosed by the invention has the advantages that, the reaction: conditions are mild, the 9 - reaction conditions are mild, and the yield 71%. of the reaction conditions is not lower than the reaction conditions . (by machine translation)

Donor Strength Determination of Pyridinylidene-amide Ligands using Their Palladium-NHC Complexes

Pyridinylidene-amides (PYAs) are a relatively new type of N-donor ligands that can exist in three isomeric forms and adopt various resonance structures. This makes them electronically flexible, and in order to evaluate their electronic profile using the Huynh electronic parameter (HEP), seven structurally diverse mixed N-heterocyclic carbenes (NHCs)/PYA palladium complexes of the type trans-[PdBr2(iPr2-bimy)(PYA)] were prepared and fully characterized by various spectroscopic and spectrometric methods. This study shows that PYAs are among the strongest, formally neutral N-donors, but they are still weaker than phosphines and organometallic ligands such as NHCs. Notably, the donating abilities of isomeric PYAs are distinct and can be further fine-tuned by the choice of two substituents making them structurally and electronically versatile. These characteristics and the ease of their preparation hold promise for a wide applicability in coordination chemistry.