Welcome to LookChem.com Sign In|Join Free
  • or

59-66-5

Post Buying Request

59-66-5 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Acetazolamide
Cas No: 59-66-5
USD $ 45.0-45.0 / Kilogram 25 Kilogram 2000 Kilogram/Day Hangzhou Fortune Biopharm Co.,LTD. Contact Supplier
acetazolamide CAS:59-66-5 Safe delivery Free of customs clearance
Cas No: 59-66-5
USD $ 1.0-10.0 / Kilogram 1 Kilogram 5000 Kilogram/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Acetazolamide
Cas No: 59-66-5
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
High quality low price Acetazolamide Cas 59-66-5 with good service
Cas No: 59-66-5
USD $ 60.0-65.0 / Kilogram 1 Kilogram 30 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Acetazolamide
Cas No: 59-66-5
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Acetazolamide manufacturer with low price
Cas No: 59-66-5
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Acetazolamide
Cas No: 59-66-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Acetazolamide
Cas No: 59-66-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
59-66-5 Acetazolamide
Cas No: 59-66-5
No Data 1 Metric Ton 20 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
Pharmaceutical Grade CAS 59-66-5 with competitive price
Cas No: 59-66-5
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier

59-66-5 Usage

References

Forwand, S. A., et al. "Effect of acetazolamide on acute mountain sickness." New England Journal of Medicine279.16(1968):839.
Cox, S. N., E. Hay, and A. C. Bird. "Treatment of chronic macular edema with acetazolamide." Archives of Ophthalmology 106.9(1988):1190.
Supuran, Claudiu T. "Acetazolamide for the treatment of idiopathic intracranial hypertension." Expert Review of Neurotherapeutics15.8(2015):851.
Kassamali, R, and D. A. Sica. "Acetazolamide: a forgotten diuretic agent." Cardiology in Review 19.6(2011):276.
Lucas, M., and M. Brown. "Acetazolamide Reduces Hospital Admissions and Length of Stay in Refractory Heart Failure Patients." Heart Lung & Circulation 20.Suppl 2(2011):S6-S6.
https://www.rxlist.com/acetazolamide-drug.htm
https://en.wikipedia.org/wiki/Acetazolamide

Reactivity Profile

A weak acid and a diazo derivative. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Uses

carbonic anhydrase inhibitor, diuretic, antiglaucoma

Fire Hazard

Flash point data for Acetazolamide are not available; however, Acetazolamide is probably combustible.

Purification Methods

It is recrystallised from water. [Roblin & Clapp J Am Chem Soc 72 4890 1950, Beilstein 27 III/IV 8219.]

General Description

White to yellowish-white fine crystalline powder. No odor or taste.

Description

Acetazolamide is a drug used for the treatment of glaucoma,epilepsy,altitude sickness,periodic paralysis, chronic macular edema, idiopathic intracranial hypertension, andheart failure. It can also been used for the treatment of altitude sickness, increased intracranial pressure and neuromuscular disorders. In addition, it also has significant effect of diuretic. It belongs to the carbonic anhydrase inhibitorfamilies of medication. It works by decreasing the amount ofhydrogen ionsandbicarbonatein the body.

Air & Water Reactions

Insoluble in water.

Brand name

Diamox (Duramed).

Chemical Properties

White Solid
InChI:InChI=1/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)

59-66-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (97582)  Acetazolamide  analytical standard 59-66-5 97582-100MG 600.21CNY Detail
USP (1005004)  Acetazolamide  United States Pharmacopeia (USP) Reference Standard 59-66-5 1005004-2G 4,662.45CNY Detail
Sigma-Aldrich (Y0001084)  Acetazolamide for system suitability  European Pharmacopoeia (EP) Reference Standard 59-66-5 Y0001084 1,880.19CNY Detail
Sigma-Aldrich (A0100000)  Acetazolamide  European Pharmacopoeia (EP) Reference Standard 59-66-5 A0100000 1,880.19CNY Detail
Alfa Aesar (L07562)  Acetazolamide, 99%    59-66-5 25g 361.0CNY Detail
Alfa Aesar (L07562)  Acetazolamide, 99%    59-66-5 5g 130.0CNY Detail

59-66-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name acetazolamide

1.2 Other means of identification

Product number -
Other names Cidamex

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59-66-5 SDS

59-66-5Synthetic route

5-amino-1, 3, 4-thiadiazole-2-sulfonamide
14949-00-9

5-amino-1, 3, 4-thiadiazole-2-sulfonamide

thioacetic acid
507-09-5

thioacetic acid

acetazolamide
59-66-5

acetazolamide

Conditions
ConditionsYield
With 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate In acetonitrile at 20℃; for 5h; Irradiation;76%
5-acetamido-1,3,4-thiadiazolyl-2-sulfonyl chloride
32873-57-7

5-acetamido-1,3,4-thiadiazolyl-2-sulfonyl chloride

acetazolamide
59-66-5

acetazolamide

Conditions
ConditionsYield
With 1,1,1-triphenylsilylamine In acetonitrile for 1h; Reflux; Inert atmosphere;74%
With ammonium hydroxide In water for 1h; Cooling with ice;72%
With ammonium hydroxide at 20℃; for 0.5h;46%
2-acetylamino-5-benzylmercapto-1,3,4-thiadiazole
64387-67-3

2-acetylamino-5-benzylmercapto-1,3,4-thiadiazole

acetazolamide
59-66-5

acetazolamide

Conditions
ConditionsYield
With chlorine; acetic acid anschliessendes Behandeln mit fluessigem NH3;
Stage #1: 2-acetylamino-5-benzylmercapto-1,3,4-thiadiazole With chlorine; acetic acid at 50℃; for 0.5h;
Stage #2: With ammonia
Stage #1: 2-acetylamino-5-benzylmercapto-1,3,4-thiadiazole With water; chlorine; acetic acid at 5℃; for 0.5h;
Stage #2: With ammonia

A

acetazolamide
59-66-5

acetazolamide

B

C20H25NO5
68905-61-3

C20H25NO5

Conditions
ConditionsYield
With water at 37℃; pH=7.4;
PMA

PMA

A

acetazolamide
59-66-5

acetazolamide

B

C20H23NO5
687620-14-0

C20H23NO5

Conditions
ConditionsYield
With water at 37℃; pH=7.4;

A

acetazolamide
59-66-5

acetazolamide

B

C24H25NO5

C24H25NO5

Conditions
ConditionsYield
With water at 37℃; pH=7.4;
succinic acid anhydride
108-30-5

succinic acid anhydride

acetazolamide
59-66-5

acetazolamide

acetazolamide
59-66-5

acetazolamide

5-amino-1, 3, 4-thiadiazole-2-sulfonamide
14949-00-9

5-amino-1, 3, 4-thiadiazole-2-sulfonamide

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 4h; Reflux;100%
With hydrogenchloride In methanol; water for 18h; Reflux;98%
With hydrogenchloride; water In methanol for 18h; Reflux;98%
acetazolamide
59-66-5

acetazolamide

Acetazolamide sodium salt

Acetazolamide sodium salt

Conditions
ConditionsYield
With sodium hydroxide In water at 55℃; for 2h;99%
acetazolamide
59-66-5

acetazolamide

cobalt(II) chloride
7646-79-9

cobalt(II) chloride

Co(5-acetamido-1,3,4-thiadiazole-2-sulphonamide)2(NH3)2

Co(5-acetamido-1,3,4-thiadiazole-2-sulphonamide)2(NH3)2

Conditions
ConditionsYield
With NH3 In ethanol addn. of the ligand to a soln. of CoCl2 in ethanol, warming, stirring, addn. of NH3; filtn. of ppt., washing (EtOH), dried at 40 °C, elem. anal.;98%
acetazolamide
59-66-5

acetazolamide

5-amino-2-sulfamoyl-1,3,4-thiadiazole monohydrochloride
120208-98-2

5-amino-2-sulfamoyl-1,3,4-thiadiazole monohydrochloride

Conditions
ConditionsYield
With hydrogenchloride for 3h; Reflux;96%
With hydrogenchloride In water for 3h; Reflux;96%
With hydrogenchloride for 3h; Reflux;96%
With hydrogenchloride In ethanol for 3h; Inert atmosphere; Reflux;65%
With hydrogenchloride; water at 60℃; for 2h; Heating / reflux;
acetazolamide
59-66-5

acetazolamide

zinc(II) chloride
7646-85-7

zinc(II) chloride

Zn(5-acetamido-1,3,4-thiadiazole-2-sulphonamide)2(NH3)2

Zn(5-acetamido-1,3,4-thiadiazole-2-sulphonamide)2(NH3)2

Conditions
ConditionsYield
With NH3 In methanol addn. of NH3 to a soln. of ligand in methanol, addn. of ZnCl2, stirring, pptn. on standing at room temp. for 3 h; filtn., washing (water), drying at 60°C, elem. anal.;96%
acetazolamide
59-66-5

acetazolamide

Trimethylenediamine
109-76-2

Trimethylenediamine

copper(ll) bromide
7789-45-9

copper(ll) bromide

bis(5-acetamidato-1,3,4-thiadiazole-2-sulfonamide-N)bis(1,3-propanediamine)copper(II)

bis(5-acetamidato-1,3,4-thiadiazole-2-sulfonamide-N)bis(1,3-propanediamine)copper(II)

Conditions
ConditionsYield
In ethanol solid ligand was dissolved in hot soln. of CuBr2 in EtOH with heating and stirring, propanediamine was added dropwise with stirring; soln. was stored at 4°C for 3-4 d, crystals were collected, elem. anal.;90%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

acetazolamide
59-66-5

acetazolamide

[(η6-p-cymene)RuCl2(κN11-AcmH2)]

[(η6-p-cymene)RuCl2(κN11-AcmH2)]

Conditions
ConditionsYield
In acetone for 7h; Reflux;90%
In acetone at 20℃; for 12h; Temperature;47%
acetazolamide
59-66-5

acetazolamide

5-amino-2-sulfonamido-1,3,4-thiadiazole

5-amino-2-sulfonamido-1,3,4-thiadiazole

Conditions
ConditionsYield
In methanol; chloroform87%
In methanol; chloroform87%
zinc(II) perchlorate

zinc(II) perchlorate

acetazolamide
59-66-5

acetazolamide

Zn{C2N2S(SO2NH)(NHCOCH3)}2(NH3)2
109751-05-5

Zn{C2N2S(SO2NH)(NHCOCH3)}2(NH3)2

Conditions
ConditionsYield
With NH3 In ammonia NH3 (liquid); dissolving of the ligand and the Zn-salt in NH3, dropwise combining of the both soln.; slow evapn. of NH3 for 2 months;87%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

acetazolamide
59-66-5

acetazolamide

[(η6-p-cymene)RuCl(κ2N8,N10-acetazolamide)]

[(η6-p-cymene)RuCl(κ2N8,N10-acetazolamide)]

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20℃; for 16h;86%
acetazolamide
59-66-5

acetazolamide

C21H24ClNO6
1373769-10-8

C21H24ClNO6

C25H29N5O9S2
1338056-91-9

C25H29N5O9S2

Conditions
ConditionsYield
With sodium hydroxide at 8℃; pH=8.5 - 9.5;82%
acetazolamide
59-66-5

acetazolamide

C24H30ClNO6
1373769-14-2

C24H30ClNO6

C28H35N5O9S2
1338056-94-2

C28H35N5O9S2

Conditions
ConditionsYield
With sodium hydroxide at 8℃; pH=8.5 - 9.5;82%
acetazolamide
59-66-5

acetazolamide

C25H33ClN4O6
1373769-15-3

C25H33ClN4O6

C29H38N8O9S2
1338056-97-5

C29H38N8O9S2

Conditions
ConditionsYield
With sodium hydroxide at 8℃; pH=8.5 - 9.5;81%
acetazolamide
59-66-5

acetazolamide

C21H24ClNO6S

C21H24ClNO6S

C25H29N5O9S3

C25H29N5O9S3

Conditions
ConditionsYield
With sodium hydroxide at 8℃; pH=8.5 - 9.5;81%
acetazolamide
59-66-5

acetazolamide

3-methoxy-2-hydroxybenzaldehyde
148-53-8

3-methoxy-2-hydroxybenzaldehyde

C12H12N4O5S2

C12H12N4O5S2

Conditions
ConditionsYield
In water for 0.0416667h; Time; Microwave irradiation; Green chemistry;79%
acetazolamide
59-66-5

acetazolamide

C24H28ClNO6
1373769-20-0

C24H28ClNO6

C28H33N5O9S2

C28H33N5O9S2

Conditions
ConditionsYield
With sodium hydroxide at 8℃; pH=8.5 - 9.5;78%
(tris(3-cumenyl-5-methylpyrazolyl)borate)ZnOH

(tris(3-cumenyl-5-methylpyrazolyl)borate)ZnOH

acetazolamide
59-66-5

acetazolamide

ZnB(C3HN2(CH3)(C6H4CH(CH3)2))3((HNSO2)C2N2S(NHC(O)CH3))*2CH3OH

ZnB(C3HN2(CH3)(C6H4CH(CH3)2))3((HNSO2)C2N2S(NHC(O)CH3))*2CH3OH

Conditions
ConditionsYield
In methanol; dichloromethane; water stirred at room temp. for 1 d in a solvent mixture of CH2Cl2/CH3OH/H2O=10/8/3; solvent removed in vac.; recrystd. (methanol) at -25°C; elem. anal.;76%
acetazolamide
59-66-5

acetazolamide

C24H30ClNO6S
1373769-16-4

C24H30ClNO6S

C28H35N5O9S3
1338057-00-3

C28H35N5O9S3

Conditions
ConditionsYield
With sodium hydroxide at 8℃; pH=8.5 - 9.5;75%
acetazolamide
59-66-5

acetazolamide

C30H31ClN2O6
1373769-43-7

C30H31ClN2O6

C34H36N6O9S2
1338057-17-2

C34H36N6O9S2

Conditions
ConditionsYield
With sodium hydroxide at 8℃; pH=8.5 - 9.5;75%
acetazolamide
59-66-5

acetazolamide

C20H22ClNO4

C20H22ClNO4

PMA

PMA

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water at 8℃; pH=7 - 9.5;70%
acetazolamide
59-66-5

acetazolamide

C22H26ClNO7
1373769-21-1

C22H26ClNO7

C26H31N5O10S2
1338057-08-1

C26H31N5O10S2

Conditions
ConditionsYield
With sodium hydroxide at 8℃; pH=8.5 - 9.5;68%
acetazolamide
59-66-5

acetazolamide

C20H24ClNO4

C20H24ClNO4

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water at 8℃; pH=7 - 9.5;65%
copper(II) perchlorate hexahydrate

copper(II) perchlorate hexahydrate

acetazolamide
59-66-5

acetazolamide

[Co(diethylenetriamine)(acetazolamidato)]ClO4 * H2O

[Co(diethylenetriamine)(acetazolamidato)]ClO4 * H2O

Conditions
ConditionsYield
With NaOH; diethylenetriamine In methanol addn. of stoich. amt. of acetazolamide soln. contg. 1 equiv. of NaOH to Cu(ClO4)2, stirring (several min), dropwise addn. of diethylenetriamine,(stirring, pptn.); filtration, washing (MeOH), drying; elem. anal.;62%
acetazolamide
59-66-5

acetazolamide

copper(II) nitrate

copper(II) nitrate

ethylenediamine
107-15-3

ethylenediamine

bis(5-acetamidato-1,3,4-thiadiazole-2-sulfonamide-O)bis(1,2-ethanediamine)copper(II)

bis(5-acetamidato-1,3,4-thiadiazole-2-sulfonamide-O)bis(1,2-ethanediamine)copper(II)

B

bis(5-acetamidato-1,3,4-thiadiazole-2-sulfonamide)bis(1,2-ethanediamine)copper(II)

bis(5-acetamidato-1,3,4-thiadiazole-2-sulfonamide)bis(1,2-ethanediamine)copper(II)

Conditions
ConditionsYield
In ethanol heated, stirred, ethanediamine was added dropwise with stirring; filtered (violet product), soln. was stored at room temp. for 4-24 h, crystals (purple) were collected, elem. anal.;A 60%
B 30%
acetazolamide
59-66-5

acetazolamide

C24H24ClNO4

C24H24ClNO4

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water at 8℃; pH=7 - 9.5;55%
acetazolamide
59-66-5

acetazolamide

salicylaldehyde
90-02-8

salicylaldehyde

C11H10N4O4S2
1167412-20-5

C11H10N4O4S2

Conditions
ConditionsYield
In methanol; water for 4h; Reflux;54%
In methanol; water for 4h; Reflux;
acetazolamide
59-66-5

acetazolamide

propargyl bromide
106-96-7

propargyl bromide

5-N-(prop-2-yn-1-yl)acetamido-1,3,4-thiadiazole-2-sulfonamide

5-N-(prop-2-yn-1-yl)acetamido-1,3,4-thiadiazole-2-sulfonamide

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;45.3%
zinc perchlorate

zinc perchlorate

acetazolamide
59-66-5

acetazolamide

1,5,9-triazacyclododecane
294-80-4

1,5,9-triazacyclododecane

NHS(O)2C2N2SNHC(O)CH3Zn(NH(CH2)3)3(1+)*ClO4(1-)={(C4H5N4O3S2)Zn(NH(CH2)3)3}(ClO4)

NHS(O)2C2N2SNHC(O)CH3Zn(NH(CH2)3)3(1+)*ClO4(1-)={(C4H5N4O3S2)Zn(NH(CH2)3)3}(ClO4)

Conditions
ConditionsYield
In acetonitrile dropwise addn. of soln. of Zn(ClO4)2*6H20 and acetazolamide to soln. of (12)aneN3 in MeCN; filtration, crystn. on evapn. (slow, room temp.); elem. anal.;40%

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields