59831-02-6Relevant academic research and scientific papers
Mixed ligand, palladium(II) and platinum(II) complexes of tertiary diphosphineswithS-1H benzo[d] imidazole-2-yl benzothioate
Ali, Karwan Omer,Mohammad, Hikmat Ali,Gerber, Thomas,Hosten, Eric
, p. 584 - 592 (2017)
Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary diphosphinesdppm. dppp and dppf with Thioester ligand S-1H benzo[d] imidazole-2-yl benzothioate (HSBIBT) have been prepared by the reaction of PdCl2 and PtCl2/
Synthesis, characterisation, crystal structures and biological studies of palladium(ii) complexes containing 5-(2-hydroxy-3-methoxy-phenyl)-2,4-dihydro[1,2,4]triazole-3-thione derivatives
Shanmugapriya,Dallemer,Prabhakaran
, p. 18850 - 18864 (2018)
A series of new Pd(ii) complexes (1-4) were obtained from the reactions between K2[PdCl4], 3-methoxysalicylaldehyde-4(N)-substituted thiosemicarbazone [H2L1-H2L4] and 1,3-bis(diphenylphosphino)propane [dppp]. All the complexes were characterized by various spectroscopic techniques (IR, electronic, 1H-NMR and ESI-MS). The crystal structures of complexes 2 and 4 have been determined by single crystal X-ray diffraction. The binding affinity and binding mode of the palladium complexes (1-4) towards calf-thymus (CT) DNA and BSA (Bovine Serum Albumin) were studied by using UV-vis and fluorescence emission spectroscopy. These results showed that the binding of the complexes to DNA is through electrostatic interaction and the quenching of the complexes is static. Further they cleaved supercoiled DNA pBR322 without any added external agents. The alterations in the secondary structure of BSA by the Pd(ii) complexes were confirmed by synchronous and three dimensional fluorescence spectroscopy. The cytotoxicity of the complexes was evaluated by an MTT assay in the MCF-7 cell line and complex 3 exhibited significant activity (IC50 = 5.60 ± 0.04 μM), which was comparable with those of the other complexes. The morphological changes assessed by acridine orange and ethidium bromide staining revealed that the cell death occurred through apoptosis.
Meso -Tetra-(4-pyridyl)porphyrin/palladium(ii) complexes as anticancer agents
Alves, Kamilla M.,Ayalla, Alejando P.,Batista, Alzir A.,Dutra, Jocely De L.,Ellena, Javier,Gon?alves, Pablo J.,Guedes, Adriana P. M.,Honorato, Jo?o,Li?o, Luciano M.,Velozo-Sa, Vivianne S.
, p. 16254 - 16264 (2021/11/27)
This study reports the synthesis, structural characterization and cytotoxic activity of four new palladium/pyridylporphyrin complexes, with the general formula {TPyP[PdCl(P-P)]4}(PF6)4, where P-P is 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp), 1,2-bis(diphenylphosphino)butane (dppb) or 1,1′-bis(diphenylphosphino)ferrocene (dppf). The complexes were characterized by elemental analysis, and by FT-IR, UV/Vis, 1H and 31P{1H} NMR (1D/2D) spectroscopy. The slow evaporation of a methanolic solution of {TPyP[PdCl(dppb)]4}(PF6)4 (in an excess of NaBF4 salt) resulted in single crystals suitable for X ray diffraction, allowing the determination of the tridimensional structure of this complex, which crystallized in the P21/a space group. The cytotoxicity of the complexes against MDA-MB-231 (breast cancer cells) and MCF-10A (non-tumor breast cancer cells), was determined by the colorimetric MTT method, which revealed that all four complexes show selective indexes close to 1.2, lower than that of cisplatin for the same cells (12.12). The interaction of the complexes with CT-DNA was evaluated by UV-visible and viscosity measurements and it was determined that the complexes interact moderately with CT-DNA, probably by H-bonding/π-π stacking and electrostatic interactions. This journal is
Triphenylene based metal-pyridine cages
Berton, Giacomo,Lorenzetto, Tommaso,Borsato, Giuseppe,Sgarbossa, Paolo,Santo, Claudio,Visentin, Fabiano,Fabris, Fabrizio,Scarso, Alessandro
supporting information, (2019/10/02)
C3-symmetric pyridine containing tris-benzyl-O-substituted hexahydroxytriphenylene derivatives were prepared and used in combination with square-planar Pd(II) and Pt(II) complexes for the self-assembly of molecular cages in solution. The formation of a trigonal bipyramid M3L2 cage was demonstrated by multinuclear NMR analyses and pseudo 2D DOSY experiments and supported by semi-empirical calculations.
Discrete Air-Stable Nickel(II)-Palladium(II) Complexes as Catalysts for Suzuki-Miyaura Reactions
Zhao, Tiankun,Ghosh, Pokhraj,Martinez, Zachary,Liu, Xufeng,Meng, Xianggao,Darensbourg, Marcetta Y.
supporting information, p. 1822 - 1827 (2017/05/15)
Four novel bidentate phosphine-Pd complexes coordinated by NiN2S2 metallodithiolate ligands were synthesized and characterized, including XRD analysis; these redox-active complexes are stable in air, and they survive column chromatography on silica gel. The Ni-Pd bimetallic complexes are demonstrated to be precatalyst for Suzuki-Miyaura cross-coupling reactions. The best of these has an overall yield of over 99% under only 1% catalyst loading. The role of NiN2S2 as a stabilizing bidentate ligand that is also oxidizable may account for its efficacy in the support of the catalysis.
A double (mortars; concrete ; artificial stone) alkane dichloride method for the preparation of palladium complexes (by machine translation)
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Paragraph 0021; 0022; 0023; 0024; 0025, (2017/02/24)
The invention discloses a double (mortars; concrete ; artificial stone) alkane second palladium chloride complex preparation method, the method is:a, preparation chlorine arrowhead acid solution; b, the double (mortars; concrete ; artificial stone) alkane adding N, N-dimethyl formamide (mortars; concrete ; artificial stone) is made of the alkane-N, N-dimethyl formamide solution; three, under stirring condition to the double (mortars; concrete ; artificial stone) N of paraffins, N-dimethyl formamide solution adds by drops the chlorine arrowhead acid solution, stirring reaction after the completion of the dropping, cooling after-filtration, the filter cake obtained; four, washing the filter cake, the filter cake after washing is then subjected to vacuum drying, to get double (mortars; concrete ; artificial stone) alkane second palladium chloride complex. The invention directly the palladium source is palladium sponge, to double with the ligand chlorine arrowhead acid (mortars; concrete ; artificial stone) alkane in the solvent DMF in one-step synthesis target product, omits the intermediate palladium chloride, palladium chloride process for the preparation of acetonitrile, has the advantages of simple technique, cycle is short, low cost, and the like. (by machine translation)
Palladium-Catalyzed Aminomethylamination and Aromatization of Aminoalkenes with Aminals via C-N Bond Activation
Li, Lixin,Liu, Peipei,Su, Yijin,Huang, Hanmin
supporting information, p. 5736 - 5739 (2016/11/17)
Thanks to the facile imine-enamine tautomerization, the β,γ-unsaturated hydrazones have been successfully utilized as surrogates of aminodienes for realizing the Pd-catalyzed tandem aminomethylamination/aromatization reaction with aminals via C-N bond activation. This direct and operationally simple protocol provides a fundamentally novel strategy to synthesize aromatic heterocycles from alkenes in the absence of external oxidant and base. Mechanistic studies suggested that aminal not only functioned as an aminomethyl source but also acted as formal oxidant and inner base to promote the aromatization.
Palladium-Catalyzed Formal Insertion of Carbenoids into Aminals via C-N Bond Activation
Qin, Guiping,Li, Lixin,Li, Jiawen,Huang, Hanmin
supporting information, p. 12490 - 12493 (2015/10/19)
A new strategy for selective insertion of metal carbenes into C-N bond has been developed via Pd-catalyzed C-N bond activation. A series of aminals and α-diazoesters with different substituents were successfully incorporated even in 0.1 mol % of catalyst under mild conditions, affording a wide range of α,β-diamino acid esters with quarternary carbon-centers. Preliminary mechanistic studies uncovered that the unique electrophilic cyclopalladated species could easily react with diazoacetates to generate a Pd-carbenoid intermediate which was involved in the catalytic cycle.
Anion transport across phospholipid membranes mediated by a diphosphine-Pd(ii) complex
Milano, Domenico,Benedetti, Barnaba,Boccalon, Mariangela,Brugnara, Andrea,Iengo, Elisabetta,Tecilla, Paolo
supporting information, p. 9157 - 9160 (2014/08/05)
The [Pd(dppp)(OTf)2] complex acts as an efficient transporter of halide anions, in particular the biologically relevant chloride anion, across a phospholipid bilayer. This journal is the Partner Organisations 2014.
Hydrogen-bonding-promoted oxidative addition and regioselective arylation of olefins with aryl chlorides
Ruan, Jiwu,Iggo, Jonathan A.,Berry, Neil G.,Xiao, Jianliang
supporting information; scheme or table, p. 16689 - 16699 (2011/02/23)
The first, general, and highly efficient catalytic system that allows a wide range of activated and unactivated aryl chlorides to couple regioselectively with olefins has been developed. The Heck arylation reaction is likely to be controlled by the oxidative addition of ArCl to Pd(0). Hence, an electron-rich diphosphine, 4-MeO-dppp, was introduced to facilitate the catalysis. Solvent choice is critical, however; only sluggish arylation is observed in DMF or DMSO, whereas the reaction proceeds well in ethylene glycol at 0.1-1 mol % catalyst loadings, displaying excellent regioselectivity. Mechanistic evidence supports that the arylation is turnover-limited by the oxidative addition step and, most importantly, that the oxidative addition is accelerated by ethylene glycol, most likely via hydrogen bonding to the chloride at the transition state as shown by DFT calculations. Ethylene glycol thus plays a double role in the arylation, facilitating oxidative addition and promoting the subsequent dissociation of chloride from Pd(II) to give a cationic Pd(II)-olefin species, which is key to the regioselectivity observed.
