624-79-3 Usage
Uses
Principal use in toxicology
was in the characterization of cytochrome P450 isozymes.
Ethyl isocyanide and the reduced cytochrome form a
characteristic optical difference spectrum with two peaks in
the Soret Region (type III). The pH equilibrium point (the pH
at which the two peaks are of equal height) varies between different
isozymes.
Preparation
CAUTION: The reaction and distillation should be conducted behind a safety shield. Precautions for handling toxic cyanides should be observed.To a three-necked flask equipped with a condenser and ground glass stirrer (or Hershberg stirrer) is added 116 gm (0.75 mole) of ethyl iodide and 100 gm (0.75 mole) of silver cyanide. The mixture is refluxed for 2 hr, the stirrer blade raised, the mixture cooled, filtered (see Note a), the solid washed with ether, dried, and 260 gm of a 50% solution of potassium cyanide (2.0 moles) added. The reaction mixture is distilled to afford a mixture of isonitrile and water (see Note b). The crude isonitrile 49.5- 52.3 gm (90-95%) is separated after being salted out of the water. The isonitrile is washed twice with 24-ml portions of ice-cold saturated sodium chloride solution, dried over magnesium sulfate, and fractionally distilled, to afford 25.9-30.3 gm (47-55%), b.p. 77-79°C (760 mm Hg).
Check Digit Verification of cas no
The CAS Registry Mumber 624-79-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 624-79:
(5*6)+(4*2)+(3*4)+(2*7)+(1*9)=73
73 % 10 = 3
So 624-79-3 is a valid CAS Registry Number.
InChI:InChI=1/C3H5N/c1-3-4-2/h3H2,1H3
624-79-3Relevant articles and documents
Bolton et al.
, p. 1 (1969)
The Question of Tautomerism of Alkylnitrile and Isonitrile Cations
Chess, Edward K.,Lapp, R. L.,Gross, Michael L.
, p. 475 - 480 (2007/10/02)
The isomeric pairs+. and +. and +. and +. have been established as stable, noninterconverting structures.The conclusion derives from studies of collision induced decomposition spectra.The same conclusion pertains for the ions +. and +., and for +., +. and HNCCHCHCNH>+..The energy barrier of a -hydrogen shift, a possible isomerization mechanism, is determined to be at least 163kJ mol-1 for the +. and +. pair, and the barrier may be as high as 318kJ*mol-1.The C3H5N and C4H4N2 radical cations decompose before they can be activated with 318 kJ mol-1 of internal energy.
