6482-34-4

Usage

Uses

Used in Pharmaceutical Synthesis:
Diisopropyl carbonate is used as a synthetic intermediate for the production of Huperizine A (H826000), a reversible alkaloid inhibitor of AChE. Diisopropyl carbonate has the potential to serve as a therapeutic agent for Alzheimer's disease, as it demonstrates the ability to cross the blood-brain barrier and reduce cell death induced by glutamate in primary cultures derived from various regions of the embryonic rat brain.
Used in Alzheimer's Disease Treatment:
In the field of neurology, Diisopropyl carbonate plays a crucial role as a component in the synthesis of Huperizine A, which is being investigated for its potential to treat Alzheimer's disease. Diisopropyl carbonate's ability to inhibit AChE and cross the blood-brain barrier makes it a promising candidate for further research and development in this area.

InChI:InChI=1/C20H26O3/c1-15-6-11-19(18(14-15)20(2,3)4)23-13-12-22-17-9-7-16(21-5)8-10-17/h6-11,14H,12-13H2,1-5H3

Upstream product

• 24425-00-1 diisopropyl pyrocarbonate 
• 201230-82-2 carbon monoxide 
• 683-60-3 sodium isopropylate 
• 108-23-6 isopropyl chloroformate 
• 67-63-0 isopropyl alcohol 
• 75-44-5 phosgene 
• 24425-18-1 isopropyl N,N-difluorocarbamate 
• 4447-60-3 Triisopropoxymethan 
• 75-15-0 carbon disulfide 
• 56-23-5 tetrachloromethane 
• 463-71-8 thiophosgene 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 584-08-7 potassium carbonate 
• 75-26-3 isopropyl bromide 

Downstream Products

• 89145-28-8 1-methyl-4,5-dihydro-5-(2-fluorophenyl)-2-isopropoxycarbonylaminoimidazole 
• 89145-32-4 1-methyl-4,5-dihydro-5-(2-chlorophenyl)-2-isopropoxycarbonylaminoimidazole 
• 156783-96-9 ethyl 2,2,2-trifluoroethyl carbonate 
• 156783-98-1 methyl (2,2,3,3-tetrafluoropropyl) carbonate 
• 156783-95-8 2,2,2-trifluoroethyl methyl carbonate 
• 943-57-7 4-isopropyl phenyl carbonate 
• 67-63-0 isopropyl alcohol 
• 72727-72-1 (Z)-2-(hex-3-en-1-yloxy)tetrahydro-2H-pyran 
• 1189537-08-3 (E)-iso-propyl 2-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-pent-2-enoate 
• 1189537-07-2 (E)-iso-propyl 2-ethyl-5-(tetrahydro-2H-pyran-2-yloxy)-pent-2-enoate 
• 26011-68-7 methyl N-(2-phenylethyl)carbamate 
• 63982-24-1 isopropyl N-(2-phenylethyl)carbamate 
• 103897-19-4 3-benzyltetrahydro-2H-1,3-oxazin-2-one 
• 2453-03-4 trimethylene carbonate 

Relevant academic research and scientific papers

METHOD FOR PRODUCING CARBONATE ESTERS, AND CATALYTIC STRUCTURE FOR PRODUCING CARBONATE ESTERS

Provided are a method for producing carbonate esters, and a catalytic structure for producing carbonate esters, whereby solid catalyst powder formation and detachment are suppressed and superior carbonate ester reaction efficiency is yielded when a catalytic structure constituted by a sufficient quantity of a cerium-oxide-containing solid catalyst supported on a substrate is used. The method for producing carbonate esters includes reacting a monohydric alcohol and carbon dioxide in the presence of a catalytic structure and a hydrating agent. The catalytic structure includes a substrate and a catalytic layer that is formed on at least a portion of the surface of the substrate and contains a solid catalyst and an inorganic binder. The solid catalyst contains cerium oxide. The supported quantity of the solid catalyst is 15 g/m2 to 200 g/m2, inclusive. The inorganic binder contains silica and/or alumina.

Uranyl(VI) Triflate as Catalyst for the Meerwein-Ponndorf-Verley Reaction

Catalytic transformation of oxygenated compounds is challenging in f-element chemistry due to the high oxophilicity of the f-block metals. We report here the first Meerwein-Ponndorf-Verley (MPV) reduction of carbonyl substrates with uranium-based catalysts, in particular from a series of uranyl(VI) compounds where [UO2(OTf)2] (1) displays the greatest efficiency (OTf = trifluoromethanesulfonate). [UO2(OTf)2] reduces a series of aromatic and aliphatic aldehydes and ketones into their corresponding alcohols with moderate to excellent yields, using iPrOH as a solvent and a reductant. The reaction proceeds under mild conditions (80 °C) with an optimized catalytic charge of 2.3 mol % and KOiPr as a cocatalyst. The reduction of aldehydes (1-10 h) is faster than that of ketones (>15 h). NMR investigations clearly evidence the formation of hemiacetal intermediates with aldehydes, while they are not formed with ketones.

Phosgene-free synthesis of symmetric bis(polyfluoroalkyl) carbonates

A phosgene-free synthesis of symmetric bis(polyfluoroalkyl) carbonates involves the transesterification of diphenyl carbonate with polyfluoroalkanols promoted by stoichiometric amounts of titanium(iv) alkoxides.

METHOD FOR PRODUCING CARBONIC ESTER

To achieve a method for producing a carbonic ester at a high yield by a simple process while suppressing formation of by-products, for example, a method for producing an aliphatic carbonic ester. The above problem is solved by a method for producing a carbonic ester, the method including a carbonic ester formation reaction in which an alcohol and carbon dioxide are reacted in the presence of an aromatic nitrile compound and a catalyst, wherein the water content in the alcohol used in the carbonic ester formation reaction is 0.10% by mass or less.

Method of manufacturing Dialkyl carbonate using carbon dioxide

In the embodiment of the present invention consists of a carbon dioxide using the d alkyl car this [thu [thu] which it sees a manufacturing method is provided other [...] number one, alcohol, imidazolium cation and bicarbonate mixing negative catalyst and bases the solvent to form a mixture, said mixture by mixing said reactants including injecting carbon dioxide for generating an agitating the manufacturing method characterized in that the d alkyl car this [thu [thu] which it sees a number [...] substrate. (by machine translation)

Transfer hydrogenation of cyclic carbonates and polycarbonate to methanol and diols by iron pincer catalysts

Herein, we report the first example on the use of an earth-abundant metal complex as the catalyst for the transfer hydrogenation of cyclic carbonates to methanol and diols. The advantage of this method is the use of isopropanol as the hydrogen source, thus avoiding the handling of flammable hydrogen under high pressure. The reaction offers an indirect route for the reduction of CO2 to methanol. In addition, poly(propylene carbonate) was converted to methanol and propylene glycol. This methodology can be considered as an attractive opportunity for the chemical recycling of polycarbonates.

The design of efficient carbonate interchange reactions with catechol carbonate

Catechol carbonate (CC) has been investigated as an innovative and highly active reactant for carbonate interchange reactions (CIRs). Under mild conditions (atmospheric pressure, and 60-80°C), the selective synthesis of symmetric aliphatic carbonates (ROCO2R) has been achieved by the reaction of a slight excess of both primary and secondary alcohols with CC in the presence of NaOMe or MgO as a catalyst. Quantitative conversions have been reached in only 1 hour and products have been isolated in yields of up to 58% for dibutylcarbonate. Of note is that the reaction of glycerol with CC also proceeded under similar conditions (40-60°C, 1 atm) to afford glycerol carbonate (96-98%). The comparison of the reactivity of CC with that of conventional dialkyl carbonates, including dimethyl carbonate (DMC) and ethylene carbonate (EC), proved the superior performance of CC in all the investigated CIR processes. Accordingly, a mechanism has been formulated based on the leaving group ability of a catecholate anion originating from CC.

PROCESS FOR THE PREPARATION OF ORGANIC CARBONATE DERIVATES

The present invention relates in general terms to a new process for the preparation of organic carbonate derivatives, cyclic or linear by a trans carbonation reaction between PCC and a suitable aliphatic alcohol, in the presence of a homogeneous or heterogeneous basic catalyst; the process allows to optimize yields and selectivities of the obtained products, especially in the case of the preparation of symmetrical linear or cyclic carbonates starting from the corresponding primary alcohols.

Palladium catalyzed oxidative carbonylation of alcohols: Effects of diphosphine ligands

The catalytic activity of a series of palladium diphosphine complexes of the type [PdX2(P∩P)] has been studied in the oxidative carbonylation of i-PrOH with p-benzoquinone as an oxidant. Diphosphine ligands have been chosen in order to cover a wide range of bite angles and electronic and steric parameters. Their properties have been correlated with the catalytic activity and selectivity of the reaction. The best catalytic performance has been achieved with weakly coordinating anions as well as non-bulky and electron-donating P∩P ligands with a relatively wide bite angle yet capable of maintaining a cis-coordination, such as cis-[Pd(OTs)2(pMeO-dppf)]. These results and those on the reactivity of dicarboalkoxy species of the type cis-[Pd(COOMe)2(P∩P)] toward reductive elimination, which is a crucial step in oxalate formation, suggest that the slow step of the catalysis depends on the nature of the P∩P ligand.

Production of carbonate

PROBLEM TO BE SOLVED: To provide a production method which can also obtain a carbonic ester at even a mild reaction condition, controls the discharge of a by-product, and can easily separate/purify the carbonic ester.SOLUTION: The method of producing a carbonic ester includes a step in which a compound of formula (1) is made to react with carbon dioxide under the presence of a polar organic solvent. In the formula, R-Reach independently are a monovalent hydrocarbon group; and Rand Rmay mutually combine directly or through other groups.