7617-74-5Relevant articles and documents
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
Yamano, Yumiko,Tsuboi, Kazuhito,Hozaki, Yuki,Takahashi, Kiyohiro,Jin, Xing-Hua,Ueda, Natsuo,Wada, Akimori
, p. 3658 - 3665 (2012/07/28)
N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N-palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities (IC50 = 5.7 and 11.8 μM), with much weaker effects on FAAH. These simple structures would provide a scaffold for further improvement in NAAA inhibitory activity.
Aldose epimerization by Ni(II): effect of ether-containig alkylenediamine ligands
Osanai, Shuichi,Inaba, Kiyoshi,Yoshikawa, Sadao
, p. 289 - 295 (2007/10/02)
Several N-substituted ethylenediamine (en) Ni(II) derivatives containing ether linkages were prepared in order to study the effect of ligand structure on C-2 epimerization of aldohexoses.The reagent consisted of a Ni(II)-alkyenediamine derivative in methanol.The presence of ether linkages in the ligand increased the solubilty of the complexes, and resulted in an increase in the rate of epimerization.Epimerization occured rapidly under mild conditions, and the same equilibrium point was reached regardless of whether the reaction was started from glucose or mannose.Among the ligands studied, N,N'-dialkylethylenediamine was the most effective in C-2 epimerization.