799-87-1

Basic information

• Product Name: methyl bis(4-nitrophenyl) phosphate
• Synonyms: O-METHYL O,O-BIS(4-NITROPHENYL) PHOSPHORATE; Phosphoric acid, methyl bis(4-nitrophenyl) ester
• CAS NO: 799-87-1
• Molecular Formula: C₁₃H₁₁N₂O₈P
• Molecular Weight: 354.2088
• Mol File: 799-87-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 476.4°C at 760 mmHg
• Flash Point: 241.9°C
• Density: 1.5g/cm³
• Vapor Pressure: 8.79E-09mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: methyl bis(4-nitrophenyl) phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl bis(4-nitrophenyl) phosphate(799-87-1)
• EPA Substance Registry System: methyl bis(4-nitrophenyl) phosphate(799-87-1)

Safety Data

• Hazardous Substances Data: 799-87-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 3871-20-3 tris(p-nitrophenyl)phosphate 
• 645-15-8 Bis(p-nitrophenyl) phosphate 
• 124-41-4 sodium methylate 
• 186581-53-3 diazomethane 
• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 
• 52625-61-3 diphosphoric acid tetrakis-(4-nitro-phenyl ester) 

Downstream Products

• 512-56-1 trimethyl phosphite 
• 950-35-6 methyl paraoxon 
• 42893-52-7 Methyl-butyl-p-nitrophenyl-phosphat 
• 109044-99-7 diphosphoric acid-1,2-dimethyl ester-1,2-bis-(4-nitro-phenyl ester) 
• 74-88-4 methyl iodide 
• 32586-84-8 methyl 4-nitrophenyl phosphate diester sodium salt 
• 824-78-2 4-nitrophenol sodium salt 
• 100-02-7 4-nitro-phenol 
• 812-00-0 methylphosphate 
• 98334-28-2 phosphoric acid-(4-amino-phenyl ester)-methyl ester 
• 15930-83-3 methyl (4-nitrophenyl)phosphate 
• 97194-51-9 phosphoric acid benzyl ester-methyl ester 

Relevant articles and documents

Design of experiments on the transesterification of tris(p-nitrophenyl) phosphate with sodium methoxide

A design of experiments was conducted to study the transesterification of tris(p-nitrophenyl) phosphate with sodium methoxide. The factorial design was performed to check the experimental conditions that favored ths yield of bis(p-nitrophenyl) methyl phosphate in a semi-batch process. The experiments were performed using a Mettler RC1 calorimeter. The reaction temperature, the addition order of reagents and the time spent in those additions were analyzed at two different levels. The results showed the addition order of reagents as the most important factor to guarantee the improvement of the reaction yielding bis(p-nitrophenyl) methyl phosphate. It was demonstrated that the temperature has a small effect on the reaction yield between 5 and 30°C. An important effect was observed with regard to the addition time of reagents and yield: when the tris(p-nitrophenyl)phosphate is added to the methoxide solution (58% on average) while no effect was observed when the methoxide solution was added to the phosphate (87% on average). Theses results indicated that the addition could be made in times shorter than five minutes under the latter condition. Copyright Taylor & Francis Inc.

Solvent isotope effects as a probe of general catalysis and solvation in phosphoryl transfer

Phosphoryl transfer to methanol from PNNN, PMNN, and PMMN exhibits general base catalysis by acetate ion but no detectable catalysis by acetic acid. For PNNN, acetate catalysis produces normal solvent isotope effects that arise from a one-proton catalytic bridge in the transition state. The proton inventory for the least reactive substrate PMMN is suggestive of transition-state stabilization, while the proton inventory for the most reactive substrate PNNN suggests only generalized transition-state solvation. Furthermore, the proton inventory for PMNN suggests an intermediate situation. The data are consistent with a model in which transition states with exterior concentrations of charge favor stabilization of the charge by isotope-fractionating one-proton bridges, while transition states with distributed charge favor stabilization of the charge by many distributed sites.

Enzymatic preparation of an optically active phosphotriester, asymmetric only at phosphorus.

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