86-39-5Relevant academic research and scientific papers
COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF
-
, (2021/03/23)
The present invention relates to a compound for an organic electronic element. To the present invention, an organic electronic element having high luminous efficiency, low driving voltage, and high heat resistance can be provided, and color purity and lifetime of the organic electronic element can be improved.
Catalyst-Controlled Stereoselective Barton–Kellogg Olefination
Schmidt, Tanno A.,Sparr, Christof
, p. 23911 - 23916 (2021/10/08)
Overcrowded alkenes are expeditiously prepared by the versatile Barton–Kellogg olefination and have remarkable applications as functional molecules owing to their unique stereochemical features. The induced stereodynamics thereby enable the controlled motion of molecular switches and motors, while the high configurational stability prevents undesired isomeric scrambling. Bistricyclic aromatic enes are prototypical overcrowded alkenes with outstanding stereochemical properties, but their stereocontrolled preparation was thus far only feasible in stereospecific reactions and with chiral auxiliaries. Herein we report that direct catalyst control is achieved by a stereoselective Barton–Kellogg olefination with enantio- and diastereocontrol for various bistricyclic aromatic enes. Using Rh2(S-PTAD)4 as catalyst, several diazo compounds were selectively coupled with a thioketone to give one of the four anti-folded overcrowded alkene stereoisomers upon reduction. Complete stereodivergence was reached by catalyst control in combination with distinct thiirane reductions to provide all four stereoisomers with e.r. values of up to 99:1. We envision that this strategy will enable the synthesis of topologically unique overcrowded alkenes for functional materials, catalysis, energy- and electron transfer, and bioactive compounds.
Ultraviolet-light-induced aerobic oxidation of benzylic C(sp3)-H of alkylarenes under catalyst- and additive-free conditions
Zhou, Jiacheng,Li, Meichao,Li, Tianci,Li, Chunmei,Hu, Xinquan,Jin, Liqun,Sun, Nan,Hu, Baoxiang,Shen, Zhenlu
, (2021/02/01)
A mild and efficient system has been discovered for the synthesis of α-aryl carbonyl compounds via oxidation of benzylic C–H to C[dbnd]O bonds. This ultraviolet-light-mediated oxygenation reaction exhibited excellent substrate scope including various xanthenes, thioxanthenes and 9, 10-dihydroacridines and afforded the corresponding ketones with good to excellent yields under catalyst- and additive-free conditions at room temperature.
Novel synthesis method of chlorolucanthone
-
Paragraph 0022; 0029; 0033-0034; 0038-0039; 0043-0044; 0048, (2020/10/21)
The invention discloses a novel synthesis method of chlorolucanthone, and belongs to the technical field of chemical engineering. The method comprises the following steps: firstly, adding a sodium hydrosulfide solution into a hydrogen sulfide generator, then dropwise adding an acid into the hydrogen sulfide generator, and guiding generated gas into a preheated pipeline reactor; pumping preheated p-dichlorobenzene into the pipeline reactor, reacting the p-dichlorobenzene with hydrogen sulfide gas, cooling a reaction product to obtain liquid and gas, and rectifying and purifying the liquid to obtain mercaptochlorobenzene; secondly, adding a reaction solvent and an alkali into a flask, stirring, adding mercaptochlorobenzene and o-chlorobenzoic acid, carrying out a reflux reaction, and carrying out aftertreatment after the reaction is finished so as to obtain an intermediate 2-carboxyl-4'-chlorodiphenyl sulfide; and finally, adding 2-carboxyl-4'-chlorodiphenyl sulfide into concentrated sulfuric acid, carrying out an intramolecular cyclization dehydration reaction, and purifying after the reaction is ended so as to obtain the target product. The method disclosed by the invention is simple and convenient to operate, mild in reaction condition, clean and environment-friendly, and high in product yield and purity.
A metal-free heterogeneous photocatalyst for the selective oxidative cleavage of CC bonds in aryl olefins: via harvesting direct solar energy
Das, Shoubhik,Hatami, Nareh,Jooss, Christian,Lange, Niklas Simon,Ronge, Emanuel,Schilling, Waldemar,Zhang, Yu
supporting information, p. 4516 - 4522 (2020/08/10)
Selective cleavage of CC bonds is highly important for the synthesis of carbonyl containing fine chemicals and pharmaceuticals. Novel methodologies such as ozonolysis reactions, Lemieux-Johnson oxidation reaction etc. already exist. Parallel to these, catalytic methods using homogeneous catalysts also have been discovered. Considering the various advantages of heterogeneous catalysts such as recyclability and stability, couple of transition metal-based heterogeneous catalysts have been applied for this reaction. However, the pharmaceutical industries prefer to use metal-free catalysts (especially transition metal-free) to avoid further leaching in the final products. This is for sure a big challenge to an organic chemist and to the pharmaceutical industries. To make this feasible, a mild and efficient protocol has been developed using polymeric carbon nitrides (PCN) as metal-free heterogeneous photocatalysts to convert various olefins into the corresponding carbonyls. Later, this catalyst has been applied in the gram scale synthesis of pharmaceutical drugs using direct solar energy. Detailed mechanistic studies revealed the actual role of oxygen, the catalyst, and the light source.
Ultraviolet light promoted synthesis method of thioxanthone compounds
-
Paragraph 0029-0030, (2020/06/02)
The invention discloses an ultraviolet light promoted synthesis method of a thioxanthone compound. The preparation method comprises the following steps: carrying out a reaction in 1,2-dichloroethane at normal temperature under the condition of 380-385 nm ultraviolet irradiation by taking a thioxanthone compound as a reaction substrate and taking oxygen in air as an oxidizing agent, and after the reaction is finished, carrying out separation treatment to obtain the thioxanthone compound. According to the synthesis method disclosed by the invention, the traditional heating reaction is replaced by an illumination reaction, so that energy sources can be saved, and any catalyst is not used.
A medicinal composition for combining thioxanthone paclitaxel and STAT3 inhibitor
-
Paragraph 0075; 0076; 0077; 0078, (2019/01/23)
A medicinal composition for combining thioxanthone paclitaxel and STAT3 inhibitor, comprising an active ingredient and a pharmaceutically acceptable adjuvant, characterized in that the active ingredient is composed of paclitaxel and a STAT3 inhibitor represented by formula (I) (shown in the description), and the mass ratio of the paclitaxel to the STAT3 inhibitor represented by formula (I) in theactive ingredient is (0.18 to 0.32): 1. The compound has an effect on MDA having persistently activated STAT3 activity-MB-468 cell, DU-145 cells had good inhibitory effect.
STAT3 inhibitors and application thereof
-
Paragraph 0139-0143, (2019/01/20)
The invention belongs to the field of medical chemistry, relates to STAT3 inhibitors and an application thereof and particularly relates to compounds for inhibiting the signal transduction and transcription activator-3, a pharmaceutical composition containing the compound and a use of the compounds or the pharmaceutical composition as cancer treatment drugs. The compounds can well inhibit MDA-MB-468 cells and DU-145 cells with sustained STAT3 activity.
Thioxanthone Signal Transducer and Activator of Transcription-3 (STAT3) inhibitor and application thereof
-
Paragraph 0074; 0075; 0076; 0077; 0078, (2019/02/27)
The invention belongs to the field of medical chemistry, and relates to a thioxanthone Signal Transducer and Activator of Transcription-3 (STAT3) inhibitor as shown by a formula (I) and application thereof, in particular to a compound with STAT3 inhibiting effects, a drug composition containing the compound, and the application of the compound or the drug composition as a cancer treatment drug. The compound has remarkable inhibiting effects on MDA-MB-468 cells and DU-145 cells with continuously activated STAT3 activity. (The formula is as shown in the description).
Thioxanthone STAT3 (signal transducer and activator of transcription-3) inhibitor maleate crystal form A and application thereof
-
Paragraph 0078-0082, (2019/09/17)
The invention belongs to the field of medical chemistry and relates to a thioxanthone STAT3 (signal transducer and activator of transcription-3) inhibitor shown as formula (I) and an application thereof, in particular to compounds with a STAT3 inhibition function, pharmaceutical composition containing the compounds and an application of the compounds or the pharmaceutical composition as cancer treatment drugs. The compounds have good inhibition functions on MDA-MB-468 cells and DU-145 cells with continuously activated STAT3 activity.
