89566-59-6Relevant articles and documents
Palladium-catalyzed B-diarylation of diethylaminoborane for the synthesis of diarylborinic acids
Igarashi, Takuya,Shimazumi, Ryoma,Tobisu, Mamoru
supporting information, p. 760 - 763 (2020/07/10)
The palladium-catalyzed synthesis of diarylborinic acid derivatives by intermolecular cross-coupling between aryl iodides and (amino)dihydrideborane is reported. The key to success of the reaction is the use of a less bulky diethylaminoborane reagent, which facilitates the second B-arylation.
Borinic Acids via Direct Arylation of Amine-Borane Complexes: An Air- and Water-Stable Boron Source
Richard, Jimmy,Birepinte, Mélodie,Charbonnier, Jean Baptiste,Liautard, Virginie,Pinet, Sandra,Pucheault, Mathieu
, p. 736 - 744 (2017/02/15)
A synthesis of borinic acids and borinates was optimized using amine-borane complexes as a water and air insensitive borylating agent. The reaction operates under convenient conditions using a non-cryogenic temperature and with no flash chromatography, and it gives no boron impurities. The reaction proceeds through a tandem dehydrogenation-double addition mechanism.
Borinic acid catalysed peptide synthesis
El Dine, Tharwat Mohy,Rouden, Jacques,Blanchet, Jér?me
supporting information, p. 16084 - 16087 (2015/11/10)
The catalytic synthesis of peptides is a major challenge in the modern organic chemistry hindered by the well-established use of stoichiometric coupling reagents. Herein, we describe for the first time that borinic acid is able to catalyse this reaction under mild conditions with an improved activity compared to our recently developed thiophene-based boronic acid. This catalyst is particularly efficient for peptide bond synthesis affording dipeptides in good yields without detectable racemization.
Compounds for the Treatment of Periodontal Disease
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Page/Page column 64, (2008/06/13)
Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.
Anti-viral uses of borinic acid complexes
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Page/Page column 14-15, (2008/06/13)
Compositions and methods of use of borinic acid complexes, especially hydroxyquinoline, imidazole and picolinic acid derivatives, as anti-viral agents as well as therapeutic agents for the treatment of diseases caused by viruses are described.
Antibiotics containing borinic acid complexes and methods of use
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, (2008/06/13)
The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH
Benkovic, Stephen J.,Baker, Stephen J.,Alley,Woo, Youn-Hi,Zhang, Yong-Kang,Akama, Tsutomu,Mao, Weimin,Baboval, Justin,Rajagopalan, P. T. Ravi,Wall, Mark,Kahng, Lyn Sue,Tavassoli, Ali,Shapiro, Lucy
, p. 7468 - 7476 (2007/10/03)
As bacteria continue to develop resistance toward current antibiotics, we find ourselves in a continual battle to identify new antibacterial agents and targets. We report herein a class of boron-containing compounds termed borinic esters that have broad spectrum antibacterial activity with minimum inhibitory concentrations (MIC) in the low microgram/mL range. These compounds were identified by screening for inhibitors against Caulobacter crescentus CcrM, an essential DNA methyltransferase from Gram negative α-proteobacteria. In addition, we demonstrate that borinic esters inhibit menaquinone methyltransferase in Gram positive bacteria using a new biochemical assay for MenH from Bacillus subtilis. Our data demonstrate the potential for further development of borinic esters as antibacterial agents as well as leads to explore more specific inhibitors against two essential bacterial enzymes.
ANTI-PARASITIC USES OF BORINIC ACID COMPLEXES
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Page/Page column 50, (2010/02/15)
Compositions and methods of use of borinic acid complexes, especially hydroxyquinoline, imidazole and picolinic acid derivatives as anti-parasitic agents as well as therapeutic agents for the treatment of diseases caused by parasite are described.
BORON-CONTAINING COMPOUNDS AND METHODS OF USE
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Page/Page column 38, (2010/02/15)
Methods of treating and/or preventing surface infections, such as acne, in an animal, such as a human being, using antibiotics incorporating borinic acid complexes, especially picolinic acid derivatives, are disclosed, along with compositions of these ant
DNA Methyltransferase inhibitors
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Page 27, (2008/06/13)
A compound of the formula or a pharmaceutically acceptable salt thereof,whereinR1, R2, and R3 are the same or different and are independently hydrogen, lower alkyl, aryl or substituted aryl, lower alkoxy, lower alkoxyalkyl, or cycloalkyl or cycloalkyl alkoxy, where each cycloalkyl group has from 3-7 members, where up to two of the cycloalkyl members are optionally hetero atoms selected from oxygen and nitrogen, and where any member of the alkyl, aryl or cycloalkyl group is optionally substituted with halogen, lower alkyl or lower alkoxy, aryl or substituted aryl, andwhereR3 can be ribose, deoxyribose or phosphorylated derivatives thereof,whereinR1, R2, and R3 are not all hydrogen andwhereinwhen R3 is ribose, deoxyribose or phosphorylated derivatives thereof, one of R1 or R2 is not hydrogen.
