Postulated pathway for the in-situ preparation of active Pd(0) catalyst from PEPPSI, PPh3 and Ar3Bi

June 06, 2024

• Title:       

  Postulated pathway for the in-situ preparation of active Pd(0) catalyst from PEPPSI, PPh₃ and Ar₃Bi

• Image Source:

  Mechanism insight and scope of PEPPSI-catalyzed cross-coupling reaction between triarylbismuth and arylbromide

• Mark:

  Scheme 5

• Associated context:

  Such a process would involve two consecutive metatheses on Pd(II)  followed by a reductive elimination step, yielding the Pd(0) species and the dimer Ar-Ar in the same quantities. (Scheme 5) The –Cl / -pTol exchange on Pd may be similar to those described by Jain and coll. as really fast and efficient.^[22] Effectively, a kinetic study carried out by GC/MS with internal standard shows that Ar-Ar is produced in little quantities (<3  mol%) within 5 min using a 3 mol% loading of PEPPSI.