Methods for the formation of C-S bonds

August 22, 2024

• Title:       

  Methods for the formation of C-S bonds 

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  Double C-S bond formation Via C-H bond functionalization Synthesis of benzothiazoles and naphtho[2,1- d] thiazoles from N -substituted arylamines and elemental sulfur

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  Scheme 1

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  Recently, Itami and Segawa reported that thiophanthrenes could be synthesized via the cleavage of  C(sp2)-H bonds from napthalynes with elemental sulfur  (Scheme 1, b).13 If the C(sp2)-H bonds and C(sp3)-H bonds could be transformed into C-S bonds in a step reaction, this should be an ideal strategy for synthesis of sulfur-containing heterocyclic compounds. Herein, we report a method for synthesis of benzothiazoles via the cleavage of C(sp2)-H bonds and C(sp3)-H bonds from easily available N-substituted arylamines with elemental sulfur (Scheme 1, c).