The synthetic routes utilized for the preparation of the prerequisite alkyl

August 22, 2024

• Title:       

  The synthetic routes utilized for the preparation of the prerequisite alkyl

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  Stereoselective construction of the azabicyclic core applicable to the biologically important polyguanidinium alkaloids batzelladine A and D using a free radical cyclization

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  Scheme 1

• Associated context:

  Scheme 1 summarizes the synthetic routes utilized for the preparation of the prerequisite alkyl bromides 6a/c  and acyl selenides 6b/d for our initial study. Treatment of the secondary alcohol 4 with 3-N-benzoyl-protected uracil and thymine 3a/b under Mitsunobu conditions furnished 5a and 5b in 81% and 72% yield, respectively.