Synthesis of 2-phenylbenzothiazoles

August 22, 2024

• Title:       

  Synthesis of 2-phenylbenzothiazoles

• Image Source:

  Double C-S bond formation Via C-H bond functionalization Synthesis of benzothiazoles and naphtho[2,1- d] thiazoles from N -substituted arylamines and elemental sulfur

• Mark:

  Table 3

• Associated context:

  To further expand the substrate scope, arylamines such as anilines, 1-naphthylamines, and 2-anthranylamine instead of 2-naphthylamines were examined in this cyclization reaction  (Table 3). Under optimized reaction conditions, only electron-donating groups such as methyl, methoxyl, and N, N-dimethylamino substituted anilines could smoothly be transformed into the target products, and a close examination of the results shows that the product yield decreases in the order: (Me)2N-> MeO- > Me-.