The binding of the HIV envelope protein gp-120

August 22, 2024

• Title:       

  The binding of the HIV envelope protein gp-120

• Image Source:

  Stereoselective construction of the azabicyclic core applicable to the biologically important polyguanidinium alkaloids batzelladine A and D using a free radical cyclization

  Mark:

  Figure 1

• Associated context:

  Batzelladine A (1, Fig. 1) is particularly pertinent because it competitively inhibits the binding of the HIV envelope protein gp-120 to the human CD4 receptor with micromolar affinity. Since acquired immunodeficiency syndrome (AIDS) is associated with the progressive decline in the number of  CD4+ cells, which in turn leads to the failure of the immune system and ultimately death through sussusceptibility infection, this relationship is clearly important and mechanistically intriguing.