Optimization of reaction conditions

August 22, 2024

• Title:       

   Optimization of reaction conditions

• Image Source:

  Double C-S bond formation Via C-H bond functionalization Synthesis of benzothiazoles and naphtho[2,1- d] thiazoles from N -substituted arylamines and elemental sulfur

• Mark:

  Table 1

• Associated context:

  Inspired by our previous work on the synthesis of sulfur-containing cyclic compounds using K2S as a sulfur source, we  started our investigation by taking N-benzyl 2-naphthylamine 1a and K2S as a model substrate in DMSO at 140 °C under hydroxyl and electron-withdrawing groups such as nitryl and nitrogen atmosphere (Table 1).