Levels of Aβ1−40 in the plasma, brain, and CSF of laboratory rats 5 h after sc administration of 5, 15, and 40 mg/kg doses of 22h

June 12, 2024

• Title:       

  Levels of Aβ1−40 in the plasma, brain, and CSF of laboratory rats 5 h after sc administration of 5, 15, and 40 mg/kg doses of 22h

• Image Source:

  Acyl guanidine inhibitors of β-secretase (bACE-1): Optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis

• Mark:

  Figure 5

• Associated context:

  As shown in Figure 5, dramatic and dose-dependent reductions in plasma Aβ1−40 were observed. However, despite the robust peripheral effect, significant reductions of brain or CSF Aβ1−40 were not observed at any dose.