Levels of 22h in the plasma, brain, and CSF of laboratory rats 5 h after sc administration of 5, 15, and 40 mg/kg doses of 22h

June 12, 2024

• Title:       

  Levels of 22h in the plasma, brain, and CSF of laboratory  rats 5 h after sc administration of 5, 15, and 40 mg/kg doses of 22h

• Image Source:

  Acyl guanidine inhibitors of β-secretase (bACE-1): Optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis

• Mark:

  Figure 6

• Associated context:

  The source of the lack of Aβ reduction in the brain and CSF is readily apparent in Figure 6: although high plasma concentrations of 22h were achieved, low drug levels were observed in the brain and CSF, independent of dose.