Scope of the cross-coupling of tertiary benzylamine and R’X using optimized reaction conditions

June 13, 2024

• Title:       

  Effect of electrophile leaving group in the asymmetric coupling  reaction of 4-Tol-X with 1b to yield 2b

• Image Source:

  Scope of the cross-coupling of tertiary benzylamine and R'X using optimized reaction conditions

• Mark:

  Table 3

• Associated context:

  Electron-rich aryl triflates were good substrates (Table 3, entries 1–6). Unfortunately, electron-poor substrates were less compatible with these reaction conditions. For example, 3-CF₃C₆H₄OTf triflate formed benzyne under the basic reaction conditions (see the Supporting  Information) and 3-pyridyl triflate gave no product.