The inhibitory effects of YD-3 and its derivatives on human platelet aggregation induced by U46619, collagen, thrombin, SFLLRN, and GYPGKF

June 14, 2024

• Title:       

  The inhibitory effects of YD-3 and its derivatives on human platelet aggregation induced by U46619, collagen, thrombin, SFLLRN, and  GYPGKF

• Image Source:

  Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives

• Mark:

  Table 1

• Associated context:

  The effect of test compounds on platelet aggregation was assessed and the results are summarized in Table 1. As indicated in Table 1, the lead compound YD-3 demonstrated selective and potent inhibitory activity against GYP-GKF-induced platelet aggregation with an IC₅₀ value of 0.13 μM.