Large amounts of water could be permitted hydrolysis of MIDA boronates to increase the yield of 3aa

June 19, 2024

• Title:       

  Large amounts of water could be permitted hydrolysis of MIDA boronates to increase the yield of 3aa

• Image Source:

  Palladium-catalyzed phosphine-free direct C-H arylation of benzothiophenes and benzofurans involving MIDA boronates

• Mark:

  Figure 2

• Associated context:

  It was found that large amounts of water could be permitted hydrolysis of MIDA (CAS 4408-64-4) boronates to increase the yield of 3aa¹² [Figure 2, H₂O (%)^a]. Pleasingly,  when a small amount of CF₃SO₃H (CAS 1493-13-6) (2% of TFA (CAS 76-05-1)) was introduced into the reaction mixture, the yield of product 3aa  could be increased to 89% [Figure 2, CF₃SO₃H (%)_b].