The carboxylate function of 18a–g by condensation of N, N-diethylethylenediamine

July 16, 2024

• Title:       

  The carboxylate function of 18a–g by condensation of N, N-diethylethylenediamine

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  Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma

• Mark:

  Scheme 4

• Associated context:

  The basic side chain was easily installed on the carboxylate function of 18a–g by condensation of N, N-diethylethylenediamine in the presence of trimethylaluminium to give amides 24a–g in 38–98% yields (Scheme 4).