Catalytic Mukaiyama-Michael Reactions of 1 with 0.5 mol % of Catalyst Loading and Leading to Product 8

August 16, 2024

• Title:       

  Catalytic Mukaiyama-Michael Reactions of 1 with  0.5 mol % of Catalyst Loading and Leading to Product 8

• Image Source:

  Construction of higly functionalized diazoacetoacentates via catalytic Mukaiyama-Michael reactions

• Mark:

  Table 3

• Associated context:

  Zinc triflate is sufficiently hygroscopic to draw water into the reaction solution and cause the hydrolysis of 8. Reducing the amount of catalyst and performing the reaction in a closed apparatus resulted in good yields of 8, representative examples for which are given in Table 3.