Studies on the formation of cyclohexylamine and N-Methylcyclohexylamine (cas 100-60-7) from bromhexine in animals and man, and simultaneous determination of cyclohexylamine and N-Methylcyclohexylamine (cas 100-60-7) by gas chromatography
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Add time:07/23/2019 Source:sciencedirect.com
In order to detect cyclohexylamine and N-Methylcyclohexylamine (cas 100-60-7) simultaneously in urine, a gas chromatographic method was developed in which Chromosorb 103 (porous polymer) was found to be suitable as the column packing. The detection limits were 0.1 μg/ml of cyclohexylamine and 0.4 μg/ml of N-methylcyclohexylamine in urine. In tests on animals administered bromhexine, which contains N-methylcyclohexylamine as part of its side-chain, neither cyclohexylamine nor N-methylcyclohexylamine was detected in the urine.
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