An efficient chemodosimeter for Cu(II) ions based on hydrolysis of fluorescein and its utility in live cell imaging

Add time:07/23/2019    Source:sciencedirect.com

A new NBD-based chemodosimeter system bearing fluorescein derivative has been synthesized for the detection of Cu(II) ions. The spirocyclic form of molecular system bearing a cleavable active bond performs as a fluorescent probe for Cu2+ ion selectively towards other metal ions. The sensing mechanism of Cu2+ with fluorescein hydrazide supports hydrolytic cleavage of the amide bond, hence causing the release of fluorophore (fluorescein) and enhancement of fluorescence. The proposed chemodosimeter displays the selective detection of Cu2+ ion and has been effectively utilised for live cell imaging of Cu2+ in HeLa cells.

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