Prenatal effects of dieldrin and PHOTODIELDRIN (cas 13366-73-9) in mice and rats

Add time:07/28/2019    Source:sciencedirect.com

Doses of 1.5, 3.0, and 6.0 mg/kg/day of dieldrin and 0.15, 0.30, and 0.60 mg/kg/day of PHOTODIELDRIN (cas 13366-73-9) were administered to pregnant CD-1 mice and CD rats by gastric intubation on days 7–16 of gestation. The highest dose of dieldrin induced significant increases in liver/body weight ratios and reduced weight gain in mice, and resulted in 41% mortality in rats. The highest dose of photodieldrin also induced significant increases in mouse liver/body weight ratios, and resulted in 15% mortality in rats. Teratogenic effects were not observed. The higher doses of dieldrin induced an increase in supernumerary ribs and a concomitant decrease in ossification centers in fetal mice indicating toxicity at these dose levels. Similar changes were not found in the rat. Photodieldrin induced no apparent fetal toxicity in either species.

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