Metabolism, excretion, and tissue distribution of [14C]PHOTODIELDRIN (cas 13366-73-9) in nonhuman primates following oral administration and intravenous injection

Add time:07/29/2019    Source:sciencedirect.com

Metabolism, excretion, and body distribution of [14C]photodieldrin were studied in the rhesus monkey (Macaca mulatta) after single intravenous and repeated oral administration. After iv administration about 45 and 34% of the dose were excreted by the male and the female, respectively, during 21 days following dosing. Approximately two-thirds of the excreted radioactivity was detected in the urine. The body distribution showed high concentrations of photodieldrin and/or metabolites in adipose tissue, liver, bile, bone marrow, mesenteric lymph nodes, and adrenal cortex. Analysis of feces and urine showed the presence of several metabolites. The major metabolite was identified by mass spectrometry, infrared spectrometry, and gas chromatographical comparison as trans-photoaldrindiol which appears in the urine as glucuronic acid conjugate and as free metabolite. A second metabolite, occurring in feces and urine, appears to be a monohydroxy substituted derivative of photodieldrin.

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