Inhibition of fish brain ATPases by aldrin-transdiol, aldrin, dieldrin and PHOTODIELDRIN (cas 13366-73-9)

Add time:07/30/2019    Source:sciencedirect.com

The sensitivity of catfish, Ictalurus punctatus, brain ATPase activities to cyclodiene compounds was investigated. The ATPase system showed differences in sensitivity to aldrin, dieldrin and photodieldrin. However, aldrin-transdiol (a more terminal metabolite of dieldrin and reported as a more potent neurotoxin than dieldrin) had no effect on any ATPase activity from fish brain homogenates. Mitochondrial Mg2+ ATPase was the most sensitive ATPase to the cyclodiene compounds tested. The possibility that the neurotoxic effects of these compounds is a secondary response resulting from mitochondrial Mg2+ ATPase inhibition is discussed.

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