Follistatin-like 1 expression is decreased in the alveolar epithelium of hypoplastic rat lungs with Nitrofen (cas 13410-72-5)-induced congenital diaphragmatic hernia

Add time:07/27/2019    Source:sciencedirect.com

Background/purposePulmonary hypoplasia (PH), characterized by incomplete alveolar development, remains a major therapeutic challenge associated with congenital diaphragmatic hernia (CDH). Follistatin-like 1 (Fstl1) is a crucial regulator of alveolar formation and maturation, which is strongly expressed in distal airway epithelium. Fstl1-deficient mice exhibit reduced airspaces, impaired alveolar epithelial cell differentiation, and insufficient production of surfactant proteins similar to PH in human CDH. We hypothesized that pulmonary Fstl1 expression is decreased during alveolarization in the nitrofen-induced CDH model.

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