Expression of Prx1 and Tcf4 is decreased in the diaphragmatic muscle connective tissue of Nitrofen (cas 13410-72-5)-induced congenital diaphragmatic hernia

Add time:07/28/2019    Source:sciencedirect.com

Background/purposePleuroperitoneal folds (PPFs) are the source of the primordial diaphragm's muscle connective tissue (MCT), and developmental mutations have been shown to result in congenital diaphragmatic hernia (CDH). The protein paired-related homeobox 1 (Prx1) labels migrating PPF cells and stimulates expression of transcription factor 4 (Tcf4), a novel MCT marker that controls morphogenesis of the fetal diaphragm. We hypothesized that diaphragmatic Prx1 and Tcf4 expression is decreased in the nitrofen-induced CDH model.

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