Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of Nitrofen (cas 13410-72-5)-induced congenital diaphragmatic hernia
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Add time:08/02/2019 Source:sciencedirect.com
PurposeDevelopmental mutations that inhibit diaphragmatic and pulmonary mesenchyme formation have been shown to cause congenital diaphragmatic hernia (CDH) and pulmonary hypoplasia (PH). Kinesin family member 7 (Kif7) plays a crucial role in diaphragmatic and pulmonary morphogenesis by controlling proliferation of mesenchymal cells. Loss of Kif7 has been reported to result in diaphragmatic defects and PH. We hypothesized that diaphragmatic and pulmonary Kif7 expression is decreased in the nitrofen-induced CDH model.
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