Decreased expression of monocarboxylate transporter 1 and 4 in the branching airway epithelium of Nitrofen (cas 13410-72-5)-induced congenital diaphragmatic hernia

Add time:07/30/2019    Source:sciencedirect.com

Background/PurposeMonocarboxylate transporters (MCTs) are crucial for the maintenance of intracellular pH homeostasis in developing fetal lungs. MCT1/4 is strongly expressed by epithelial airway cells throughout lung branching morphogenesis. Functional inhibition of MCT1/4 in fetal rat lung explants has been shown to result in airway defects similar to pulmonary hypoplasia (PH) in congenital diaphragmatic hernia (CDH). We hypothesized that pulmonary expression of MCT1/4 is decreased during lung branching morphogenesis in the nitrofen model of CDH-associated PH.

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