Analysis of Oral Suspensions Containing Sulfonamides in Combination with Erythromycin ethylsuccinate (cas 1264-62-6)

Add time:08/15/2019    Source:sciencedirect.com

The sulfonamides and erythromycin ethylsuccinate in combination oral suspensions were determined by high-performance liquid chromatography and automated turbidimetry, respectively. The chromatographic procedure was rapid, specific, and stability-indicating for sulfisoxazole acetyl and the trisulfapyrimidines using a reversed-phase system with UV detection at 254 nm. Erythromycin ethylsuccinate did not interfere with the sulfonamide analysis and these compounds were assayed with relative standard deviations (RSD) ranging from ± 2.1 to ± 3.1%. Erythromycin ethylsuccinate was determined as erythromycin with RSD values of ± 1.3 or ± 3.5% without interference by the sulfonamides present.

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