Interaction of natural polyamines and DIMETHYLSILANE (cas 1111-74-6) analogues with membrane components

Add time:08/19/2019    Source:sciencedirect.com

Structural analogues of the natural polyamines which contain a Si(CH3)2 group in the central carbon chain have previously been found to be cytostatic to various tumor cell lines and to inhibit tumor cell growth in experimentally-grafted animals. We show that membrane damages induced by hexamine in chinese ovary cells are the earliest cytotoxic events. We report the interaction of natural and DIMETHYLSILANE (cas 1111-74-6) polyamines with membrane models. These polyamines protect the red blood cell membrane from hypotonic-induced cell lysis. In the case of dimethylsilane derivatives and to a lesser extent for putrescine, this stabilizing effect is followed, for longer times, by the progressive lysis of cell membranes, suggesting a biphasic interaction of polyamines with membrane components. The Langmuir's monolayer method shows that the first step of the electrostatic interaction of spermine with negatively charged phospholipids, egg phosphatidic acid (EPA), is characterised by a decrease of the mean molecular area of phospholipid. Over longer times, an increase of the mean molecular area is observed for all polyamines suggesting the insertion of their hydrocarbon chains into the monolayers. Probably as a consequence of their higher hydrophobicity, the maximal increase is obtained with dimethylsilane derivatives.

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