Full length articleAntimicrobial applications of MAPLE processed coatings based on PLGA and lincomycin functionalized magnetite nanoparticles

Add time:08/20/2019    Source:sciencedirect.com

The surface modification of implantable devices by means of laser methods represents a promising strategy towards personalized healthcare practice, providing a versatile and tunable approach to increase the patient outcome, facilitate the medical procedure and reduce the unwanted or side effects (such as biofilm-related complications). The purpose of our study was to assess the biological and microbiological performance of composite coatings based on biopolymeric spheres of poly(lactide-co-glycolide) embedded with Lincomycin-functionalized magnetite nanoparticles (PLGA/Fe3O4@LINC). The composite materials, transferred as stoichiometric and uniform nanostructured coatings by matrix assisted pulsed laser evaporation, proved enhanced biocompatibility with respect to human adipose-derived stem cells (hASCs), in terms of cellular adhesion, spreading and normal growth. Moreover, the PLGA/Fe3O4@LINC coatings exhibited great inhibitory effects against staphylococcal biofilm formation and development.

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