Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31)

Add time:08/21/2019    Source:sciencedirect.com

Several 11-ethyl-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-ones with varied functionality on the ethyl substituent have exhibited potent topoisomerase I (TOP1) targeting activity and antitumor activity. The influence of various polar substituents at the 2-position of the 11-ethyl substituent, including N-methylamine, N-isopropylamine, hydroxyl, and hydroxylamino groups, on TOP1-targeting activity and cytotoxicity was assessed. The N-methylamine and N-isopropylamine derivatives were also evaluated as antitumor agents in athymic nude mice with MDA-MB-435 human tumor xenografts. Both compounds were active as antitumor agents upon either parenteral or oral administration.

We also recommend Trading Suppliers and Manufacturers of 1-(DIMETHYLAMINO)ISOPROPYLAMINE (cas 108-15-6). Pls Click Website Link as below: cas 108-15-6 suppliers

Prev:The chemistry and stereochemistry of poly(N-alkyliminoalanes). XVII. The syntheses of poly(N-alkyliminoalanes) from dimethylamino- or methoxy-propylamines☆
Next:Synthesis of N-(dimethylamino)propyliminodialanes)