Mitsunobu reactions of nucleoside analogs using Triisopropyl phosphite (cas 116-17-6)–DIAD
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Add time:08/22/2019 Source:sciencedirect.com
Herein, we report the use of triisopropyl phosphite (TIP) as an effective substitute for triphenylphosphine in the Mitsunobu reaction of nucleoside analogs. In addition, the use of triphenyl phosphite as an alternative reagent for the expensive hexamethylphosphorous triamide (HMPT) in the Véliz–Beal bromination protocol is reported.
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