NotesAnalysis of homatropine (cas 114173-36-3) Methylbromide Dosage Forms

Add time:09/04/2019    Source:sciencedirect.com

A stability‐indicating method of analysis for homatropine (cas 114173-36-3) methylbromide in pharmaceutical formulations was developed. This method is based on the formation of a picric acid‐quaternary ammonium complex, which is adsorbed on acid‐washed diatomaceous earth in alkaline media followed by on‐column chloroform extraction. The picrate complex is measured spectrophotometrically at 365 nm. The method was selective for homatropine methylbromide in that there was no interference from its major hydrolytic decomposition products, tropinium methylbromide and mandelic acid.

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