Full Length ArticleStable thrombus formation on irradiated microvascular endothelial cells under pulsatile flow: Pre-testing ANNEXIN V (cas 136107-94-3)-thrombin conjugate for treatment of brain arteriovenous malformations

Add time:09/02/2019    Source:sciencedirect.com

BackgroundOur goal is to develop a vascular targeting treatment for brain arteriovenous malformations (AVMs). Externalized phosphatidylserine has been established as a potential biomarker on the endothelium of irradiated AVM blood vessels. We hypothesize that phosphatidylserine could be selectively targeted after AVM radiosurgery with a ligand-directed vascular targeting agent to achieve localized thrombosis and rapid occlusion of pathological AVM vessels.

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