Synthesis of the spiroketal segment (C19C34) of the Rutamycin (cas 1404-59-7)s, antifungal metabolites of Streptomyces species
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Add time:09/02/2019 Source:sciencedirect.com
A convergent synthesis of the spiroketal subunit of rutamycins A and B has been devised via Julia coupling of sulfone 14 with aldehyde 23; the pentahydroxy ketone 3 derived from 25 underwent spontaneous cyclization to spiroketal 4.
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