Short communicationSyntheses of Nα-(β-naphthylsulfonylaminoglycyl)-argininamide (cas 16709-23-2)s as potential selective synthetic thrombin inhibitorsSynthèses de Nα-(β-naphthylsulfonylaminoglycyl)-argininamide (cas 16709-23-2)s, inhibiteurs potentiels sélectifs de la thrombine synthétiques

Add time:09/24/2019    Source:sciencedirect.com

This paper deals with the synthesis of Nα-(β-naphthylsulfonylaminoglycyl)-argininamide compounds and the results of a pharmacological study (in vitro and in vivo). No thrombin inhibition was obtained with Nα-arylsulfonyl-aminoalkyl-(4-amidinophenyl)-alaninamide compounds in which the 4-amidinophenylalanyl residue was substituted by an arginyl residue.

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