Research ArticlesVeratrum Alkaloids XLVI: Structure-Activity Relationships in a Series of Analogs of the Protoveratrines

Add time:09/26/2019    Source:sciencedirect.com

In view of the significant pharmacological differences between protoveratrine A and protoveratrine B when the substances are administered orally, and of our recent revelation that the structures of the two compounds differ only in the nature of the acid moiety of the ester at C3, a series of analogs of the protoveratrines have been prepared and subjected to preliminary pharmacological evaluation. The results indicate that considerable alterations can be made in the structure of the ester affixed at C3 without greatly altering hypotensive potency.

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