Metabolic clearance rate of plasma deoxycorticosterone sulfate (cas 1420-82-2) in men and women

Add time:09/27/2019    Source:sciencedirect.com

In the present investigation, we determined the metabolic clearance rate of plasma deoxycorticosterone sulfate (cas 1420-82-2) in adult men and nonpregnant women and in one woman pregnant at 42 weeks gestation with an anencephalic fetus. The values obtained varied from 618 to 1070 l/24 h. The metabolic clearance rate of deoxycorticosterone sulfate, expressed as a function of body surface area, was 495 ± 31.7 l/24h/m2 (mean ± SEM) and was not significantly different among men and nonpregnant women. In a woman pregnant with an anencephalic fetus at 42 weeks gestation, the metabolic clearance rate of deoxycorticosterone sulfate was 644 l/24 h/m2. We suggest that the high clearance rate of this steroid 21-sulfate, compared with those of other steroid sulfates, is due to rapid excretion of deoxycorticosterone sulfate into bile and irreversible metabolism in intestine by bacterial enzymes.

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