Large-scale synthesis of Dihydrostreptomycin (cas 128-46-1) via hydrogenation of streptomycin in a membrane dispersion microreactor
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Add time:09/27/2019 Source:infona.pl
In this work, a membrane dispersion microreactor was applied for the hydrogenation of streptomycin (STR) to produce Dihydrostreptomycin (cas 128-46-1) (DHS). The reductant was dispersed into the continuous phase containing STR, leading to a significant increase in the mass-transfer specific surface area, and the conversion rate of STR reached 99.81 wt% within 3 min. In contrast, in stirred tanks, the conversion rate of STR only reached 99.5% in 30 min. Moreover, the minimum amount of KBH4 used in the membrane dispersion microreactor was about 35.71% lower than that in traditional tanks, when achieving the same conversion rate at about 99.5%.
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