Studies on the stability of corticosteroids V. The degradation pattern of hydrocortisone in aqueous solution

Add time:07/23/2019    Source:sciencedirect.com

The degradation pattern of hydrocortisone in aqueous solution was investigated utilizing an HPLC procedure capable of separating and quantitating hydrocortisone and its major degradation products. The product distribution was characterized qualitatively and quantitatively as a function of pH in the range 0—11, nature of buffers and trace metal impurities. Two major decomposition pathways were observed, an oxidative degradation leading to the formation of 21 -dehydrohydrocortisone which subsequently degraded to a 17-carboxylic acid and a 17,20-dihydroxy-21-carboxylic acid derivative, and a non-oxidative reaction giving a 17-oxo, 17-deoxy-21-aldehyde and 17-deoxy-20-hydroxy-21-carboxylic acid derivative.The analytical consequences of the formation of steroid-glyoxals (21-aldehyde derivatives) in the evaluation of the stability-indicating properties of some spectrophotometric assays for corticosteroids are discussed as are possible means to prevent the conversion of corticosteroids to these products recently characterized as potentially immunogenic substances possibly involved in corticosteroid-mediated allergic reactions.

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