High-Performance Liquid Chromatographic Determination of The Nitrate Esters Isosorbide Dinitrate, Pentaerythritol Tetranitrate, and Erythrityl Tetranitrate in Various Tablet Forms
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Add time:07/20/2019 Source:sciencedirect.com
A reliable, sensitive, and specific assay for isosorbide dinitrate, pentaerythritol tetranitrate, and erythrityl tetranitrate in sublingual, uncoated, sustained-release, and chewable dosage forms, using high-performance liquid chromatography, is described. The nitrate ester dosage forms were dissolved in methanol, filtered, and injected directly into the liquid chromatograph. A variable-wavelength UV detector, operated at 220 nm, and a reverse-phase C18 microporous silica column were employed. The mobile phase was methanol-water (40:60). The proposed method is quantitative and reproducible.
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